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HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice.

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Title: HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice.
Authors: Tyagi RK; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Jacobse J; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Willem-Alexander Children's Hospital, Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands., Li J; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States., Allaman MM; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Otipoby KL; Pandion Therapeutics, Immunology Department, Watertown, MA, United States., Sampson ER; Pandion Therapeutics, Immunology Department, Watertown, MA, United States., Wilson KT; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, United States.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, United States.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, United States., Goettel JA; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, United States.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, United States.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States.
Source: Frontiers in immunology [Front Immunol] 2021 Feb 24; Vol. 12, pp. 630204. Date of Electronic Publication: 2021 Feb 24 (Print Publication: 2021).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice.
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  Data: <searchLink fieldCode="AU" term="%22Tyagi+RK%22">Tyagi RK</searchLink>; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Jacobse+J%22">Jacobse J</searchLink>; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Willem-Alexander Children's Hospital, Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Allaman+MM%22">Allaman MM</searchLink>; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Otipoby+KL%22">Otipoby KL</searchLink>; Pandion Therapeutics, Immunology Department, Watertown, MA, United States.<br /><searchLink fieldCode="AU" term="%22Sampson+ER%22">Sampson ER</searchLink>; Pandion Therapeutics, Immunology Department, Watertown, MA, United States.<br /><searchLink fieldCode="AU" term="%22Wilson+KT%22">Wilson KT</searchLink>; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, United States.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, United States.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, United States.<br /><searchLink fieldCode="AU" term="%22Goettel+JA%22">Goettel JA</searchLink>; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, United States.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, United States.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, United States.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2021 Feb 24; Vol. 12, pp. 630204. <i>Date of Electronic Publication: </i>2021 Feb 24 (<i>Print Publication: </i>2021).
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