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Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.

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Title: Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
Authors: Wallace-Povirk A; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States., Tong N; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States., Wong-Roushar J; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States., O'Connor C; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States., Zhou X; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States., Hou Z; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States., Bao X; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States., Garcia GE; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States., Li J; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States., Kim S; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States., Dann CE 3rd; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States. Electronic address: cedann@indiana.edu., Matherly LH; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States. Electronic address: matherly@karmanos.org., Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: gangjee@duq.edu.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 May 01; Vol. 37, pp. 116093. Date of Electronic Publication: 2021 Feb 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
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  Data: Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
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  Data: <searchLink fieldCode="AU" term="%22Wallace-Povirk+A%22">Wallace-Povirk A</searchLink>; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States.<br /><searchLink fieldCode="AU" term="%22Tong+N%22">Tong N</searchLink>; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.<br /><searchLink fieldCode="AU" term="%22Wong-Roushar+J%22">Wong-Roushar J</searchLink>; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States.<br /><searchLink fieldCode="AU" term="%22O'Connor+C%22">O'Connor C</searchLink>; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.<br /><searchLink fieldCode="AU" term="%22Hou+Z%22">Hou Z</searchLink>; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States.<br /><searchLink fieldCode="AU" term="%22Bao+X%22">Bao X</searchLink>; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States.<br /><searchLink fieldCode="AU" term="%22Garcia+GE%22">Garcia GE</searchLink>; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States.<br /><searchLink fieldCode="AU" term="%22Dann+CE+3rd%22">Dann CE 3rd</searchLink>; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States. Electronic address: cedann@indiana.edu.<br /><searchLink fieldCode="AU" term="%22Matherly+LH%22">Matherly LH</searchLink>; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States. Electronic address: matherly@karmanos.org.<br /><searchLink fieldCode="AU" term="%22Gangjee+A%22">Gangjee A</searchLink>; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: gangjee@duq.edu.
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