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Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas.

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Title: Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas.
Authors: Wu J; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland. jing.wu3@nih.gov., Yuan Y; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas., Long Priel DA; Neutrophil Monitoring Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Fink D; Neutrophil Monitoring Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Peer CJ; Clinical Pharmacology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Sissung TM; Clinical Pharmacology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Su YT; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Pang Y; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Yu G; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Butler MK; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Mendoza TR; Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas., Vera E; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Ahmad S; The Clinical Center, NIH, Bethesda, Maryland., Bryla C; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Lindsley M; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Grajkowska E; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Mentges K; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Boris L; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Antony R; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Garren N; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Siegel C; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Lollo N; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Cordova C; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Aboud O; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Theeler BJ; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Burton EM; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Penas-Prado M; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Leeper H; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Gonzales J; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Armstrong TS; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Calvo KR; The Clinical Center, NIH, Bethesda, Maryland., Figg WD; Clinical Pharmacology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Kuhns DB; Neutrophil Monitoring Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Gallin JI; The Clinical Center, NIH, Bethesda, Maryland., Gilbert MR; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Jun 15; Vol. 27 (12), pp. 3298-3306. Date of Electronic Publication: 2021 Mar 30.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas.
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  Data: <searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland. jing.wu3@nih.gov.<br /><searchLink fieldCode="AU" term="%22Yuan+Y%22">Yuan Y</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Long+Priel+DA%22">Long Priel DA</searchLink>; Neutrophil Monitoring Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland.<br /><searchLink fieldCode="AU" term="%22Fink+D%22">Fink D</searchLink>; Neutrophil Monitoring Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland.<br /><searchLink fieldCode="AU" term="%22Peer+CJ%22">Peer CJ</searchLink>; Clinical Pharmacology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Sissung+TM%22">Sissung TM</searchLink>; Clinical Pharmacology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Su+YT%22">Su YT</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Pang+Y%22">Pang Y</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Yu+G%22">Yu G</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Butler+MK%22">Butler MK</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Mendoza+TR%22">Mendoza TR</searchLink>; Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Vera+E%22">Vera E</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Ahmad+S%22">Ahmad S</searchLink>; The Clinical Center, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Bryla+C%22">Bryla C</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Lindsley+M%22">Lindsley M</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Grajkowska+E%22">Grajkowska E</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Mentges+K%22">Mentges K</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Boris+L%22">Boris L</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Antony+R%22">Antony R</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Garren+N%22">Garren N</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Siegel+C%22">Siegel C</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Lollo+N%22">Lollo N</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Cordova+C%22">Cordova C</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Aboud+O%22">Aboud O</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Theeler+BJ%22">Theeler BJ</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Burton+EM%22">Burton EM</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Penas-Prado+M%22">Penas-Prado M</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Leeper+H%22">Leeper H</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Gonzales+J%22">Gonzales J</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Armstrong+TS%22">Armstrong TS</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Calvo+KR%22">Calvo KR</searchLink>; The Clinical Center, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Figg+WD%22">Figg WD</searchLink>; Clinical Pharmacology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Kuhns+DB%22">Kuhns DB</searchLink>; Neutrophil Monitoring Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland.<br /><searchLink fieldCode="AU" term="%22Gallin+JI%22">Gallin JI</searchLink>; The Clinical Center, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Gilbert+MR%22">Gilbert MR</searchLink>; Neuro-Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2021 Jun 15; Vol. 27 (12), pp. 3298-3306. <i>Date of Electronic Publication: </i>2021 Mar 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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