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CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.

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Title: CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.
Authors: Cho H; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Shen Q; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Zhang LH; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA 94720, USA., Okumura M; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA 94720, USA., Kawakami A; Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Ambrose J; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Sigoillot F; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Miller HR; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Gleim S; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Cobos-Correa A; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland., Wang Y; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland., Piechon P; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland., Roma G; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland., Eggimann F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland., Moore C; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland., Aspesi P Jr; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Mapa FA; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Burks H; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Ross NT; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Krastel P; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland., Hild M; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Maimone TJ; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA 94720, USA., Fisher DE; Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Nomura DK; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA; Innovative Genomics Institute, Berkeley, CA 94720, USA., Tallarico JA; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA 94720, USA., Canham SM; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA 94720, USA., Jenkins JL; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: jeremy.jenkins@novartis.com., Forrester WC; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: william.forrester@novartis.com.
Source: Cell chemical biology [Cell Chem Biol] 2021 Oct 21; Vol. 28 (10), pp. 1407-1419.e6. Date of Electronic Publication: 2021 Mar 31.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Cho+H%22">Cho H</searchLink>; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Shen+Q%22">Shen Q</searchLink>; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+LH%22">Zhang LH</searchLink>; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Okumura+M%22">Okumura M</searchLink>; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Kawakami+A%22">Kawakami A</searchLink>; Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Ambrose+J%22">Ambrose J</searchLink>; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Sigoillot+F%22">Sigoillot F</searchLink>; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Miller+HR%22">Miller HR</searchLink>; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Gleim+S%22">Gleim S</searchLink>; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Cobos-Correa+A%22">Cobos-Correa A</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Piechon+P%22">Piechon P</searchLink>; 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Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA; Innovative Genomics Institute, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Tallarico+JA%22">Tallarico JA</searchLink>; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Canham+SM%22">Canham SM</searchLink>; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Jenkins+JL%22">Jenkins JL</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%22101676030%22">Cell chemical biology</searchLink> [Cell Chem Biol] 2021 Oct 21; Vol. 28 (10), pp. 1407-1419.e6. <i>Date of Electronic Publication: </i>2021 Mar 31.
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