View in EDS

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Saved in:
Bibliographic Details
Title: Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.
Authors: Ponsioen B; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Post JB; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Buissant des Amorie JR; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Laskaris D; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., van Ineveld RL; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Kersten S; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Bertotti A; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy.; Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy., Sassi F; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy., Sipieter F; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.; Institut Jacques Monod, CNRS UMR 7592, Université Paris Diderot, Paris, France., Cappe B; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium., Mertens S; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Verlaan-Klink I; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Boj SF; Foundation Hubrecht Organoid Technology (HUB), Utrecht, Netherlands., Vries RGJ; Foundation Hubrecht Organoid Technology (HUB), Utrecht, Netherlands., Rehmann H; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Vandenabeele P; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium., Riquet FB; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.; University of Lille, Villeneuve d'Ascq, France., Trusolino L; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy.; Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy., Bos JL; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Snippert HJG; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. h.j.g.snippert@umcutrecht.nl.; Oncode Institute, Utrecht, Netherlands. h.j.g.snippert@umcutrecht.nl.
Source: Nature cell biology [Nat Cell Biol] 2021 Apr; Vol. 23 (4), pp. 377-390. Date of Electronic Publication: 2021 Apr 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 33795873
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Ponsioen+B%22">Ponsioen B</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Post+JB%22">Post JB</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Buissant+des+Amorie+JR%22">Buissant des Amorie JR</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Laskaris+D%22">Laskaris D</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Ineveld+RL%22">van Ineveld RL</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kersten+S%22">Kersten S</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bertotti+A%22">Bertotti A</searchLink>; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy.; Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Sassi+F%22">Sassi F</searchLink>; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Sipieter+F%22">Sipieter F</searchLink>; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.; Institut Jacques Monod, CNRS UMR 7592, Université Paris Diderot, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cappe+B%22">Cappe B</searchLink>; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Mertens+S%22">Mertens S</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Verlaan-Klink+I%22">Verlaan-Klink I</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Boj+SF%22">Boj SF</searchLink>; Foundation Hubrecht Organoid Technology (HUB), Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Vries+RGJ%22">Vries RGJ</searchLink>; Foundation Hubrecht Organoid Technology (HUB), Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Rehmann+H%22">Rehmann H</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Vandenabeele+P%22">Vandenabeele P</searchLink>; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Riquet+FB%22">Riquet FB</searchLink>; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.; University of Lille, Villeneuve d'Ascq, France.<br /><searchLink fieldCode="AU" term="%22Trusolino+L%22">Trusolino L</searchLink>; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy.; Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Bos+JL%22">Bos JL</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Snippert+HJG%22">Snippert HJG</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. h.j.g.snippert@umcutrecht.nl.; Oncode Institute, Utrecht, Netherlands. h.j.g.snippert@umcutrecht.nl.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22100890575%22">Nature cell biology</searchLink> [Nat Cell Biol] 2021 Apr; Vol. 23 (4), pp. 377-390. <i>Date of Electronic Publication: </i>2021 Apr 01.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Macmillan+Magazines+Ltd%22">Macmillan Magazines Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100890575 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4679 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214657392%22">14657392 </searchLink><i>NLM ISO Abbreviation: </i>Nat Cell Biol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=33795873
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41556-021-00654-5
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 377
    Titles:
      – TitleFull: Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ponsioen B
      – PersonEntity:
          Name:
            NameFull: Post JB
      – PersonEntity:
          Name:
            NameFull: Buissant des Amorie JR
      – PersonEntity:
          Name:
            NameFull: Laskaris D
      – PersonEntity:
          Name:
            NameFull: van Ineveld RL
      – PersonEntity:
          Name:
            NameFull: Kersten S
      – PersonEntity:
          Name:
            NameFull: Bertotti A
      – PersonEntity:
          Name:
            NameFull: Sassi F
      – PersonEntity:
          Name:
            NameFull: Sipieter F
      – PersonEntity:
          Name:
            NameFull: Cappe B
      – PersonEntity:
          Name:
            NameFull: Mertens S
      – PersonEntity:
          Name:
            NameFull: Verlaan-Klink I
      – PersonEntity:
          Name:
            NameFull: Boj SF
      – PersonEntity:
          Name:
            NameFull: Vries RGJ
      – PersonEntity:
          Name:
            NameFull: Rehmann H
      – PersonEntity:
          Name:
            NameFull: Vandenabeele P
      – PersonEntity:
          Name:
            NameFull: Riquet FB
      – PersonEntity:
          Name:
            NameFull: Trusolino L
      – PersonEntity:
          Name:
            NameFull: Bos JL
      – PersonEntity:
          Name:
            NameFull: Snippert HJG
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2021 Apr
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4679
          Numbering:
            – Type: volume
              Value: 23
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Nature cell biology
              Type: main
ResultId 1