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ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.

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Title: ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Authors: Vandyck K; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium. Electronic address: kvandyck@aligos.com., Abdelnabi R; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium., Gupta K; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Jochmans D; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium., Jekle A; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Deval J; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Misner D; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Bardiot D; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium., Foo CS; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium., Liu C; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Ren S; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Beigelman L; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Blatt LM; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Boland S; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium., Vangeel L; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium., Dejonghe S; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium., Chaltin P; Centre for Drug Design and Discovery (CD3), KU Leuven, Gaston Geenslaan 2, 3001 Leuven, Belgium; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium., Marchand A; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium., Serebryany V; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Stoycheva A; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Chanda S; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Symons JA; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA., Raboisson P; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Neyts J; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: johan.neyts@kuleuven.be.
Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 28; Vol. 555, pp. 134-139. Date of Electronic Publication: 2021 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
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  Data: <searchLink fieldCode="AU" term="%22Vandyck+K%22">Vandyck K</searchLink>; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium. Electronic address: kvandyck@aligos.com.<br /><searchLink fieldCode="AU" term="%22Abdelnabi+R%22">Abdelnabi R</searchLink>; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Gupta+K%22">Gupta K</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jochmans+D%22">Jochmans D</searchLink>; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Jekle+A%22">Jekle A</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Deval+J%22">Deval J</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Misner+D%22">Misner D</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bardiot+D%22">Bardiot D</searchLink>; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Foo+CS%22">Foo CS</searchLink>; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ren+S%22">Ren S</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Beigelman+L%22">Beigelman L</searchLink>; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Blatt+LM%22">Blatt LM</searchLink>; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Boland+S%22">Boland S</searchLink>; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vangeel+L%22">Vangeel L</searchLink>; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Dejonghe+S%22">Dejonghe S</searchLink>; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Chaltin+P%22">Chaltin P</searchLink>; Centre for Drug Design and Discovery (CD3), KU Leuven, Gaston Geenslaan 2, 3001 Leuven, Belgium; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Marchand+A%22">Marchand A</searchLink>; CISTIM Leuven vzw, Gaston Geenslaan 2, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Serebryany+V%22">Serebryany V</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Stoycheva+A%22">Stoycheva A</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chanda+S%22">Chanda S</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Symons+JA%22">Symons JA</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Dr., 2nd Floor, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Raboisson+P%22">Raboisson P</searchLink>; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Neyts+J%22">Neyts J</searchLink>; Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: johan.neyts@kuleuven.be.
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  Data: <searchLink fieldCode="JN" term="%220372516%22">Biochemical and biophysical research communications</searchLink> [Biochem Biophys Res Commun] 2021 May 28; Vol. 555, pp. 134-139. <i>Date of Electronic Publication: </i>2021 Mar 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372516 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2104 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220006291X%22">0006291X </searchLink><i>NLM ISO Abbreviation: </i>Biochem Biophys Res Commun <i>Subsets: </i>MEDLINE
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