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First-in-Human Phase I Study of ABBV-085, an Antibody-Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors.

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Title: First-in-Human Phase I Study of ABBV-085, an Antibody-Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors.
Authors: Demetri GD; Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute; Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts. gdemetri@dfci.harvard.edu., Luke JJ; Department of Medicine, The University of Chicago, Chicago, Illinois., Hollebecque A; Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France., Powderly JD 2nd; Carolina BioOncology Institute, Huntersville, North Carolina., Spira AI; Virginia Cancer Specialists, Fairfax, Virginia., Subbiah V; Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas., Naumovski L; Oncology Early Development, AbbVie Inc., Redwood City, California., Chen C; Oncology Early Development, AbbVie Inc., Redwood City, California., Fang H; Oncology Early Development, AbbVie Inc., Redwood City, California., Lai DW; Oncology Early Development, AbbVie Inc., Redwood City, California., Yue H; Oncology Early Development, AbbVie Inc., Redwood City, California., Polepally AR; Oncology Early Development, AbbVie Inc., Redwood City, California., Purcell JW; Oncology Early Development, AbbVie Inc., Redwood City, California., Robinson R; Oncology Early Development, AbbVie Inc., Redwood City, California., Sharma P; Department of Immunology, MD Anderson Cancer Center, Houston, Texas., Allison JP; Department of Immunology, MD Anderson Cancer Center, Houston, Texas., Tolcher A; South Texas Accelerated Research Therapeutics (START), San Antonio, Texas., Villalobos VM; University of Colorado - Anschutz Medical Campus, Aurora, Colorado.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Jul 01; Vol. 27 (13), pp. 3556-3566. Date of Electronic Publication: 2021 Apr 05.
Publication Type: Clinical Trial, Phase I; Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: First-in-Human Phase I Study of ABBV-085, an Antibody-Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors.
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  Data: <searchLink fieldCode="AU" term="%22Demetri+GD%22">Demetri GD</searchLink>; Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute; Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts. gdemetri@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Luke+JJ%22">Luke JJ</searchLink>; Department of Medicine, The University of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Hollebecque+A%22">Hollebecque A</searchLink>; Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Powderly+JD+2nd%22">Powderly JD 2nd</searchLink>; Carolina BioOncology Institute, Huntersville, North Carolina.<br /><searchLink fieldCode="AU" term="%22Spira+AI%22">Spira AI</searchLink>; Virginia Cancer Specialists, Fairfax, Virginia.<br /><searchLink fieldCode="AU" term="%22Subbiah+V%22">Subbiah V</searchLink>; Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Naumovski+L%22">Naumovski L</searchLink>; Oncology Early Development, AbbVie Inc., Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Oncology Early Development, AbbVie Inc., Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Fang+H%22">Fang H</searchLink>; Oncology Early Development, AbbVie Inc., Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Lai+DW%22">Lai DW</searchLink>; Oncology Early Development, AbbVie Inc., Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Yue+H%22">Yue H</searchLink>; Oncology Early Development, AbbVie Inc., Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Polepally+AR%22">Polepally AR</searchLink>; Oncology Early Development, AbbVie Inc., Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Purcell+JW%22">Purcell JW</searchLink>; Oncology Early Development, AbbVie Inc., Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Robinson+R%22">Robinson R</searchLink>; Oncology Early Development, AbbVie Inc., Redwood City, California.<br /><searchLink fieldCode="AU" term="%22Sharma+P%22">Sharma P</searchLink>; Department of Immunology, MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Allison+JP%22">Allison JP</searchLink>; Department of Immunology, MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Tolcher+A%22">Tolcher A</searchLink>; South Texas Accelerated Research Therapeutics (START), San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Villalobos+VM%22">Villalobos VM</searchLink>; University of Colorado - Anschutz Medical Campus, Aurora, Colorado.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2021 Jul 01; Vol. 27 (13), pp. 3556-3566. <i>Date of Electronic Publication: </i>2021 Apr 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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              Text: 2021 Jul 01
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