Genome-wide enhancer maps link risk variants to disease genes.

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Title: Genome-wide enhancer maps link risk variants to disease genes.
Authors: Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bergman DT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA., Guckelberger P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany., Doughty BR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Patwardhan TA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Statistics, Harvard University, Cambridge, MA, USA., Jones TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen TH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ulirsch JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA., Lekschas F; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Mualim K; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Natri HM; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Weeks EM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Munson G; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kane M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kang HY; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA., Cui A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA., Ray JP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Systems Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA., Eisenhaure TM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Collins RL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Dey K; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Pfister H; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Price AL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Epstein CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kundaje A; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Daly MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Huang H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Finucane HK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA. lander@broadinstitute.org.; Department of Biology, MIT, Cambridge, MA, USA. lander@broadinstitute.org.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. lander@broadinstitute.org.; Office of Science and Technology Policy, Executive Office of the President, White House, Washington, DC, USA. lander@broadinstitute.org., Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA. engreitz@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu.
Source: Nature [Nature] 2021 May; Vol. 593 (7858), pp. 238-243. Date of Electronic Publication: 2021 Apr 07.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-021-03446-x