Genome-wide enhancer maps link risk variants to disease genes.
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| Title: | Genome-wide enhancer maps link risk variants to disease genes. |
|---|---|
| Authors: | Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bergman DT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA., Guckelberger P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany., Doughty BR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Patwardhan TA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Statistics, Harvard University, Cambridge, MA, USA., Jones TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen TH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ulirsch JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA., Lekschas F; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Mualim K; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Natri HM; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Weeks EM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Munson G; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kane M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kang HY; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA., Cui A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA., Ray JP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Systems Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA., Eisenhaure TM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Collins RL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Dey K; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Pfister H; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Price AL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Epstein CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kundaje A; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Daly MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Huang H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Finucane HK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA. lander@broadinstitute.org.; Department of Biology, MIT, Cambridge, MA, USA. lander@broadinstitute.org.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. lander@broadinstitute.org.; Office of Science and Technology Policy, Executive Office of the President, White House, Washington, DC, USA. lander@broadinstitute.org., Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA. engreitz@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu. |
| Source: | Nature [Nature] 2021 May; Vol. 593 (7858), pp. 238-243. Date of Electronic Publication: 2021 Apr 07. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 33828297 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Genome-wide enhancer maps link risk variants to disease genes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Nasser+J%22">Nasser J</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bergman+DT%22">Bergman DT</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fulco+CP%22">Fulco CP</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Guckelberger+P%22">Guckelberger P</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Doughty+BR%22">Doughty BR</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Patwardhan+TA%22">Patwardhan TA</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Statistics, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jones+TR%22">Jones TR</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+TH%22">Nguyen TH</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ulirsch+JC%22">Ulirsch JC</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lekschas+F%22">Lekschas F</searchLink>; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mualim+K%22">Mualim K</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Natri+HM%22">Natri HM</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Weeks+EM%22">Weeks EM</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Munson+G%22">Munson G</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kane+M%22">Kane M</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kang+HY%22">Kang HY</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cui+A%22">Cui A</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ray+JP%22">Ray JP</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Systems Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Eisenhaure+TM%22">Eisenhaure TM</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Collins+RL%22">Collins RL</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dey+K%22">Dey K</searchLink>; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pfister+H%22">Pfister H</searchLink>; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Price+AL%22">Price AL</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Epstein+CB%22">Epstein CB</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kundaje+A%22">Kundaje A</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xavier+RJ%22">Xavier RJ</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Daly+MJ%22">Daly MJ</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Finucane+HK%22">Finucane HK</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hacohen+N%22">Hacohen N</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lander+ES%22">Lander ES</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. lander@broadinstitute.org.; Department of Biology, MIT, Cambridge, MA, USA. lander@broadinstitute.org.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. lander@broadinstitute.org.; Office of Science and Technology Policy, Executive Office of the President, White House, Washington, DC, USA. lander@broadinstitute.org.<br /><searchLink fieldCode="AU" term="%22Engreitz+JM%22">Engreitz JM</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. engreitz@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2021 May; Vol. 593 (7858), pp. 238-243. <i>Date of Electronic Publication: </i>2021 Apr 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0410462 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4687 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200280836%22">00280836 </searchLink><i>NLM ISO Abbreviation: </i>Nature <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41586-021-03446-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 238 Titles: – TitleFull: Genome-wide enhancer maps link risk variants to disease genes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nasser J – PersonEntity: Name: NameFull: Bergman DT – PersonEntity: Name: NameFull: Fulco CP – PersonEntity: Name: NameFull: Guckelberger P – PersonEntity: Name: NameFull: Doughty BR – PersonEntity: Name: NameFull: Patwardhan TA – PersonEntity: Name: NameFull: Jones TR – PersonEntity: Name: NameFull: Nguyen TH – PersonEntity: Name: NameFull: Ulirsch JC – PersonEntity: Name: NameFull: Lekschas F – PersonEntity: Name: NameFull: Mualim K – PersonEntity: Name: NameFull: Natri HM – PersonEntity: Name: NameFull: Weeks EM – PersonEntity: Name: NameFull: Munson G – PersonEntity: Name: NameFull: Kane M – PersonEntity: Name: NameFull: Kang HY – PersonEntity: Name: NameFull: Cui A – PersonEntity: Name: NameFull: Ray JP – PersonEntity: Name: NameFull: Eisenhaure TM – PersonEntity: Name: NameFull: Collins RL – PersonEntity: Name: NameFull: Dey K – PersonEntity: Name: NameFull: Pfister H – PersonEntity: Name: NameFull: Price AL – PersonEntity: Name: NameFull: Epstein CB – PersonEntity: Name: NameFull: Kundaje A – PersonEntity: Name: NameFull: Xavier RJ – PersonEntity: Name: NameFull: Daly MJ – PersonEntity: Name: NameFull: Huang H – PersonEntity: Name: NameFull: Finucane HK – PersonEntity: Name: NameFull: Hacohen N – PersonEntity: Name: NameFull: Lander ES – PersonEntity: Name: NameFull: Engreitz JM IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2021 May Type: published Y: 2021 Identifiers: – Type: issn-electronic Value: 1476-4687 Numbering: – Type: volume Value: 593 – Type: issue Value: 7858 Titles: – TitleFull: Nature Type: main |
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