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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response.

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Title: PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response.
Authors: Li J; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Kaneda MM; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037., Ma J; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Li M; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Shepard RM; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037., Patel K; Department of Neurosurgery, University of California, Los Angeles, CA 90095., Koga T; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Sarver A; Institute for Health Informatics, University of Minnesota, Minneapolis, MN 55455., Furnari F; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA., Xu B; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Dhawan S; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Ning J; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Zhu H; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.; Department of Pediatrics, The First Hospital of China Medical University, Shenyang 110122, China., Wu A; Department of Neurosurgery, The First Hospital of China Medical University, Shenyang 110122, China., You G; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China., Jiang T; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China., Venteicher AS; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Rich JN; Department of Medicine, Division of Regenerative Medicine, University of California San Diego, La Jolla, CA 92093., Glass CK; Department of Medicine, University of California San Diego, La Jolla, CA 92093., Varner JA; Department of Pathology, University of California San Diego, La Jolla, CA 92161., Chen CC; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455; ccchen@umn.edu.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Apr 20; Vol. 118 (16).
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response.
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  Data: <searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.<br /><searchLink fieldCode="AU" term="%22Kaneda+MM%22">Kaneda MM</searchLink>; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.<br /><searchLink fieldCode="AU" term="%22Shepard+RM%22">Shepard RM</searchLink>; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Patel+K%22">Patel K</searchLink>; Department of Neurosurgery, University of California, Los Angeles, CA 90095.<br /><searchLink fieldCode="AU" term="%22Koga+T%22">Koga T</searchLink>; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.<br /><searchLink fieldCode="AU" term="%22Sarver+A%22">Sarver A</searchLink>; Institute for Health Informatics, University of Minnesota, Minneapolis, MN 55455.<br /><searchLink fieldCode="AU" term="%22Furnari+F%22">Furnari F</searchLink>; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA.<br /><searchLink fieldCode="AU" term="%22Xu+B%22">Xu B</searchLink>; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.<br /><searchLink fieldCode="AU" term="%22Dhawan+S%22">Dhawan S</searchLink>; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.<br /><searchLink fieldCode="AU" term="%22Ning+J%22">Ning J</searchLink>; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.<br /><searchLink fieldCode="AU" term="%22Zhu+H%22">Zhu H</searchLink>; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.; Department of Pediatrics, The First Hospital of China Medical University, Shenyang 110122, China.<br /><searchLink fieldCode="AU" term="%22Wu+A%22">Wu A</searchLink>; Department of Neurosurgery, The First Hospital of China Medical University, Shenyang 110122, China.<br /><searchLink fieldCode="AU" term="%22You+G%22">You G</searchLink>; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.<br /><searchLink fieldCode="AU" term="%22Jiang+T%22">Jiang T</searchLink>; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.<br /><searchLink fieldCode="AU" term="%22Venteicher+AS%22">Venteicher AS</searchLink>; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.<br /><searchLink fieldCode="AU" term="%22Rich+JN%22">Rich JN</searchLink>; Department of Medicine, Division of Regenerative Medicine, University of California San Diego, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Glass+CK%22">Glass CK</searchLink>; Department of Medicine, University of California San Diego, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Varner+JA%22">Varner JA</searchLink>; Department of Pathology, University of California San Diego, La Jolla, CA 92161.<br /><searchLink fieldCode="AU" term="%22Chen+CC%22">Chen CC</searchLink>; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455; ccchen@umn.edu.
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