PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response.
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| Title: | PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. |
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| Authors: | Li J; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Kaneda MM; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037., Ma J; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Li M; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Shepard RM; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037., Patel K; Department of Neurosurgery, University of California, Los Angeles, CA 90095., Koga T; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Sarver A; Institute for Health Informatics, University of Minnesota, Minneapolis, MN 55455., Furnari F; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA., Xu B; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Dhawan S; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Ning J; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Zhu H; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.; Department of Pediatrics, The First Hospital of China Medical University, Shenyang 110122, China., Wu A; Department of Neurosurgery, The First Hospital of China Medical University, Shenyang 110122, China., You G; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China., Jiang T; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China., Venteicher AS; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Rich JN; Department of Medicine, Division of Regenerative Medicine, University of California San Diego, La Jolla, CA 92093., Glass CK; Department of Medicine, University of California San Diego, La Jolla, CA 92093., Varner JA; Department of Pathology, University of California San Diego, La Jolla, CA 92161., Chen CC; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455; ccchen@umn.edu. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Apr 20; Vol. 118 (16). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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