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CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancers.

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Title: CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancers.
Authors: Jung HR; Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea.; Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Korea., Oh Y; Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea.; Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Korea., Na D; Ewha Institute of Convergence Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea., Min S; Department of Life Science, Ewha Womans University, Seoul, Korea., Kang J; Department of Life Science, Ewha Womans University, Seoul, Korea., Jang D; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea., Shin S; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea., Kim J; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea., Lee SE; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea., Jeong EM; Department of Pharmacy, College of Pharmacy, Jeju National University, Jeju Special Self-Governing Province, Korea.; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju Special Self-Governing Province, Korea.; Bio-Health Materials Core-Facility Center, Jeju National University, Jeju Special Self-Governing Province, Korea.; Practical Translational Research Center, Jeju National University, Jeju Special Self-Governing Province, Korea., An JY; School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, Korea., Sung CO; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Lee WS; Department of Surgery, Gil Medical Center, Gachon University, Incheon, Korea., Lee C; Department of Life Science, Ewha Womans University, Seoul, Korea.; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Cho SY; Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Korea. csybio@snu.ac.kr.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea. csybio@snu.ac.kr.; Cancer Research Institute, Seoul National University, Seoul, Korea. csybio@snu.ac.kr.
Source: Oncogene [Oncogene] 2021 May; Vol. 40 (18), pp. 3287-3302. Date of Electronic Publication: 2021 Apr 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene
Database: MEDLINE Ultimate
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  Data: CRISPR screens identify a novel combination treatment targeting BCL-X<subscript>L</subscript> and WNT signaling for KRAS/BRAF-mutated colorectal cancers.
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  Data: <searchLink fieldCode="AU" term="%22Jung+HR%22">Jung HR</searchLink>; Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea.; Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Oh+Y%22">Oh Y</searchLink>; Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea.; Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Na+D%22">Na D</searchLink>; Ewha Institute of Convergence Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Min+S%22">Min S</searchLink>; Department of Life Science, Ewha Womans University, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Kang+J%22">Kang J</searchLink>; Department of Life Science, Ewha Womans University, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Jang+D%22">Jang D</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Shin+S%22">Shin S</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SE%22">Lee SE</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Jeong+EM%22">Jeong EM</searchLink>; Department of Pharmacy, College of Pharmacy, Jeju National University, Jeju Special Self-Governing Province, Korea.; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju Special Self-Governing Province, Korea.; Bio-Health Materials Core-Facility Center, Jeju National University, Jeju Special Self-Governing Province, Korea.; Practical Translational Research Center, Jeju National University, Jeju Special Self-Governing Province, Korea.<br /><searchLink fieldCode="AU" term="%22An+JY%22">An JY</searchLink>; School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Sung+CO%22">Sung CO</searchLink>; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+WS%22">Lee WS</searchLink>; Department of Surgery, Gil Medical Center, Gachon University, Incheon, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+C%22">Lee C</searchLink>; Department of Life Science, Ewha Womans University, Seoul, Korea.; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Cho+SY%22">Cho SY</searchLink>; Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Korea. csybio@snu.ac.kr.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea. csybio@snu.ac.kr.; Cancer Research Institute, Seoul National University, Seoul, Korea. csybio@snu.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%228711562%22">Oncogene</searchLink> [Oncogene] 2021 May; Vol. 40 (18), pp. 3287-3302. <i>Date of Electronic Publication: </i>2021 Apr 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8711562 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5594 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209509232%22">09509232 </searchLink><i>NLM ISO Abbreviation: </i>Oncogene
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