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Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.

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Title: Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Authors: Garnish SE; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Meng Y; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Koide A; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Sandow JJ; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Denbaum E; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA., Jacobsen AV; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Yeung W; Institute of Bioinformatics, University of Georgia, Athens, GA, USA., Samson AL; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Horne CR; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Fitzgibbon C; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Young SN; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Smith PPC; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Webb AI; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Petrie EJ; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Hildebrand JM; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Kannan N; Institute of Bioinformatics, University of Georgia, Athens, GA, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA., Czabotar PE; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Koide S; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA. Shohei.Koide@nyulangone.org.; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA. Shohei.Koide@nyulangone.org., Murphy JM; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. jamesm@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. jamesm@wehi.edu.au.
Source: Nature communications [Nat Commun] 2021 Apr 13; Vol. 12 (1), pp. 2211. Date of Electronic Publication: 2021 Apr 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
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