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Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.

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Title: Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.
Authors: Wing PAC; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Keeley TP; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., Zhuang X; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lee JY; Department of Biochemistry, University of Oxford, Oxford, UK., Prange-Barczynska M; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., Tsukuda S; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Morgan SB; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, Experimental Medicine, University of Oxford, Oxford, UK., Harding AC; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK., Argles ILA; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kurlekar S; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Noerenberg M; Department of Biochemistry, University of Oxford, Oxford, UK; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Thompson CP; Peter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, Oxford, UK., Huang KA; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Balfe P; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Watashi K; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan; Department of Applied Biological Science, Tokyo University of Science, Noda 278-8510, Japan., Castello A; Department of Biochemistry, University of Oxford, Oxford, UK; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Hinks TSC; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, Experimental Medicine, University of Oxford, Oxford, UK., James W; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK., Ratcliffe PJ; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK; Francis Crick Institute, London, UK., Davis I; Department of Biochemistry, University of Oxford, Oxford, UK., Hodson EJ; Francis Crick Institute, London, UK; Department of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK., Bishop T; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., McKeating JA; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. Electronic address: jane.mckeating@ndm.ox.ac.uk.
Source: Cell reports [Cell Rep] 2021 Apr 20; Vol. 35 (3), pp. 109020. Date of Electronic Publication: 2021 Apr 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.
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  Data: <searchLink fieldCode="AU" term="%22Wing+PAC%22">Wing PAC</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Keeley+TP%22">Keeley TP</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Zhuang+X%22">Zhuang X</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Prange-Barczynska+M%22">Prange-Barczynska M</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tsukuda+S%22">Tsukuda S</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Morgan+SB%22">Morgan SB</searchLink>; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, Experimental Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Harding+AC%22">Harding AC</searchLink>; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.<br /><searchLink fieldCode="AU" term="%22Argles+ILA%22">Argles ILA</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kurlekar+S%22">Kurlekar S</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Noerenberg+M%22">Noerenberg M</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Thompson+CP%22">Thompson CP</searchLink>; Peter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Huang+KA%22">Huang KA</searchLink>; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Balfe+P%22">Balfe P</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Watashi+K%22">Watashi K</searchLink>; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan; Department of Applied Biological Science, Tokyo University of Science, Noda 278-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Castello+A%22">Castello A</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Hinks+TSC%22">Hinks TSC</searchLink>; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, Experimental Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22James+W%22">James W</searchLink>; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.<br /><searchLink fieldCode="AU" term="%22Ratcliffe+PJ%22">Ratcliffe PJ</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK; Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Davis+I%22">Davis I</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hodson+EJ%22">Hodson EJ</searchLink>; Francis Crick Institute, London, UK; Department of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bishop+T%22">Bishop T</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22McKeating+JA%22">McKeating JA</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. Electronic address: jane.mckeating@ndm.ox.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2021 Apr 20; Vol. 35 (3), pp. 109020. <i>Date of Electronic Publication: </i>2021 Apr 05.
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