Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study.
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| Title: | Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M |
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| Authors: | Bakker C; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Tasker T; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK., Liptrot J; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK., Hart EP; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Klaassen ES; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Doll RJ; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Brown GA; OMass Therapeutics Ltd, Oxford, UK., Brown A; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK., Congreve M; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK., Weir M; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK., Marshall FH; Merck Sharp & Dohme Limited, London, UK., Cross DM; Cross Pharma Consulting Limited, Cambridge, UK., Groeneveld GJ; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands. ggroeneveld@chdr.nl.; Leiden University Medical Centre, Leiden, The Netherlands. ggroeneveld@chdr.nl., Nathan PJ; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK.; Department of Psychiatry, University of Cambridge, Cambridge, UK.; School of Psychological Sciences, Monash University, Melbourne, Australia. |
| Source: | Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Apr 21; Vol. 13 (1), pp. 87. Date of Electronic Publication: 2021 Apr 21. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 33883008 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M<subscript>1</subscript> receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bakker+C%22">Bakker C</searchLink>; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tasker+T%22">Tasker T</searchLink>; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK.<br /><searchLink fieldCode="AU" term="%22Liptrot+J%22">Liptrot J</searchLink>; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK.<br /><searchLink fieldCode="AU" term="%22Hart+EP%22">Hart EP</searchLink>; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Klaassen+ES%22">Klaassen ES</searchLink>; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Doll+RJ%22">Doll RJ</searchLink>; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Brown+GA%22">Brown GA</searchLink>; OMass Therapeutics Ltd, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Brown+A%22">Brown A</searchLink>; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK.<br /><searchLink fieldCode="AU" term="%22Congreve+M%22">Congreve M</searchLink>; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK.<br /><searchLink fieldCode="AU" term="%22Weir+M%22">Weir M</searchLink>; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK.<br /><searchLink fieldCode="AU" term="%22Marshall+FH%22">Marshall FH</searchLink>; Merck Sharp & Dohme Limited, London, UK.<br /><searchLink fieldCode="AU" term="%22Cross+DM%22">Cross DM</searchLink>; Cross Pharma Consulting Limited, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Groeneveld+GJ%22">Groeneveld GJ</searchLink>; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands. ggroeneveld@chdr.nl.; Leiden University Medical Centre, Leiden, The Netherlands. ggroeneveld@chdr.nl.<br /><searchLink fieldCode="AU" term="%22Nathan+PJ%22">Nathan PJ</searchLink>; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK.; Department of Psychiatry, University of Cambridge, Cambridge, UK.; School of Psychological Sciences, Monash University, Melbourne, Australia. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101511643%22">Alzheimer's research & therapy</searchLink> [Alzheimers Res Ther] 2021 Apr 21; Vol. 13 (1), pp. 87. <i>Date of Electronic Publication: </i>2021 Apr 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101511643 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1758-9193 (Electronic) <i>NLM ISO Abbreviation: </i>Alzheimers Res Ther <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=33883008 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13195-021-00816-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 87 Titles: – TitleFull: Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bakker C – PersonEntity: Name: NameFull: Tasker T – PersonEntity: Name: NameFull: Liptrot J – PersonEntity: Name: NameFull: Hart EP – PersonEntity: Name: NameFull: Klaassen ES – PersonEntity: Name: NameFull: Doll RJ – PersonEntity: Name: NameFull: Brown GA – PersonEntity: Name: NameFull: Brown A – PersonEntity: Name: NameFull: Congreve M – PersonEntity: Name: NameFull: Weir M – PersonEntity: Name: NameFull: Marshall FH – PersonEntity: Name: NameFull: Cross DM – PersonEntity: Name: NameFull: Groeneveld GJ – PersonEntity: Name: NameFull: Nathan PJ IsPartOfRelationships: – BibEntity: Dates: – D: 21 M: 04 Text: 2021 Apr 21 Type: published Y: 2021 Identifiers: – Type: issn-electronic Value: 1758-9193 Numbering: – Type: volume Value: 13 – Type: issue Value: 1 Titles: – TitleFull: Alzheimer's research & therapy Type: main |
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