Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study.
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| Title: | Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M |
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| Authors: | Bakker C; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Tasker T; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK., Liptrot J; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK., Hart EP; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Klaassen ES; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Doll RJ; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands., Brown GA; OMass Therapeutics Ltd, Oxford, UK., Brown A; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK., Congreve M; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK., Weir M; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK., Marshall FH; Merck Sharp & Dohme Limited, London, UK., Cross DM; Cross Pharma Consulting Limited, Cambridge, UK., Groeneveld GJ; Centre for Human Drug Research (CDHR), Zernikedreef 8, 2333 CL, Leiden, The Netherlands. ggroeneveld@chdr.nl.; Leiden University Medical Centre, Leiden, The Netherlands. ggroeneveld@chdr.nl., Nathan PJ; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge, CB21 6DG, UK.; Department of Psychiatry, University of Cambridge, Cambridge, UK.; School of Psychological Sciences, Monash University, Melbourne, Australia. |
| Source: | Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Apr 21; Vol. 13 (1), pp. 87. Date of Electronic Publication: 2021 Apr 21. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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