View in EDS

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.

Saved in:
Bibliographic Details
Title: Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Authors: Yankova E; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.; Storm Therapeutics Ltd, Cambridge, UK., Blackaby W; Storm Therapeutics Ltd, Cambridge, UK., Albertella M; Storm Therapeutics Ltd, Cambridge, UK., Rak J; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., De Braekeleer E; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Tsagkogeorga G; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK.; Storm Therapeutics Ltd, Cambridge, UK., Pilka ES; Evotec (UK) Ltd, Abingdon, UK., Aspris D; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.; The Center for the Study of Hematological Malignancies/Karaiskakio Foundation, Nicosia, Cyprus., Leggate D; Storm Therapeutics Ltd, Cambridge, UK., Hendrick AG; Storm Therapeutics Ltd, Cambridge, UK., Webster NA; Storm Therapeutics Ltd, Cambridge, UK., Andrews B; Storm Therapeutics Ltd, Cambridge, UK., Fosbeary R; Storm Therapeutics Ltd, Cambridge, UK., Guest P; Storm Therapeutics Ltd, Cambridge, UK., Irigoyen N; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK., Eleftheriou M; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK., Gozdecka M; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK., Dias JML; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK., Bannister AJ; The Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge, UK., Vick B; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; German Consortium for Translational Cancer Research (DKTK), Munich, Germany., Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; German Consortium for Translational Cancer Research (DKTK), Munich, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig Maximilians University München, Munich, Germany., Vassiliou GS; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; The Center for the Study of Hematological Malignancies/Karaiskakio Foundation, Nicosia, Cyprus., Rausch O; Storm Therapeutics Ltd, Cambridge, UK. oliver.rausch@stormtherapeutics.com., Tzelepis K; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK. kt404@cam.ac.uk.; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK. kt404@cam.ac.uk.; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. kt404@cam.ac.uk.; The Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge, UK. kt404@cam.ac.uk., Kouzarides T; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK. t.kouzarides@gurdon.cam.ac.uk.; The Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge, UK. t.kouzarides@gurdon.cam.ac.uk.
Source: Nature [Nature] 2021 May; Vol. 593 (7860), pp. 597-601. Date of Electronic Publication: 2021 Apr 26.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 33902106
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Yankova+E%22">Yankova E</searchLink>; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.; Storm Therapeutics Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Blackaby+W%22">Blackaby W</searchLink>; Storm Therapeutics Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Albertella+M%22">Albertella M</searchLink>; Storm Therapeutics Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rak+J%22">Rak J</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22De+Braekeleer+E%22">De Braekeleer E</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tsagkogeorga+G%22">Tsagkogeorga G</searchLink>; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK.; Storm Therapeutics Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pilka+ES%22">Pilka ES</searchLink>; Evotec (UK) Ltd, Abingdon, UK.<br /><searchLink fieldCode="AU" term="%22Aspris+D%22">Aspris D</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.; The Center for the Study of Hematological Malignancies/Karaiskakio Foundation, Nicosia, Cyprus.<br /><searchLink fieldCode="AU" term="%22Leggate+D%22">Leggate D</searchLink>; Storm Therapeutics Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hendrick+AG%22">Hendrick AG</searchLink>; Storm Therapeutics Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Webster+NA%22">Webster NA</searchLink>; Storm Therapeutics Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Andrews+B%22">Andrews B</searchLink>; Storm Therapeutics Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Fosbeary+R%22">Fosbeary R</searchLink>; Storm Therapeutics Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Guest+P%22">Guest P</searchLink>; Storm Therapeutics Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Irigoyen+N%22">Irigoyen N</searchLink>; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Eleftheriou+M%22">Eleftheriou M</searchLink>; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gozdecka+M%22">Gozdecka M</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dias+JML%22">Dias JML</searchLink>; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bannister+AJ%22">Bannister AJ</searchLink>; The Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vick+B%22">Vick B</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; German Consortium for Translational Cancer Research (DKTK), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jeremias+I%22">Jeremias I</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; German Consortium for Translational Cancer Research (DKTK), Munich, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig Maximilians University München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vassiliou+GS%22">Vassiliou GS</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; The Center for the Study of Hematological Malignancies/Karaiskakio Foundation, Nicosia, Cyprus.<br /><searchLink fieldCode="AU" term="%22Rausch+O%22">Rausch O</searchLink>; Storm Therapeutics Ltd, Cambridge, UK. oliver.rausch@stormtherapeutics.com.<br /><searchLink fieldCode="AU" term="%22Tzelepis+K%22">Tzelepis K</searchLink>; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK. kt404@cam.ac.uk.; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK. kt404@cam.ac.uk.; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. kt404@cam.ac.uk.; The Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge, UK. kt404@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Kouzarides+T%22">Kouzarides T</searchLink>; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK. t.kouzarides@gurdon.cam.ac.uk.; The Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge, UK. t.kouzarides@gurdon.cam.ac.uk.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2021 May; Vol. 593 (7860), pp. 597-601. <i>Date of Electronic Publication: </i>2021 Apr 26.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0410462 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4687 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200280836%22">00280836 </searchLink><i>NLM ISO Abbreviation: </i>Nature <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=33902106
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41586-021-03536-w
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 597
    Titles:
      – TitleFull: Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yankova E
      – PersonEntity:
          Name:
            NameFull: Blackaby W
      – PersonEntity:
          Name:
            NameFull: Albertella M
      – PersonEntity:
          Name:
            NameFull: Rak J
      – PersonEntity:
          Name:
            NameFull: De Braekeleer E
      – PersonEntity:
          Name:
            NameFull: Tsagkogeorga G
      – PersonEntity:
          Name:
            NameFull: Pilka ES
      – PersonEntity:
          Name:
            NameFull: Aspris D
      – PersonEntity:
          Name:
            NameFull: Leggate D
      – PersonEntity:
          Name:
            NameFull: Hendrick AG
      – PersonEntity:
          Name:
            NameFull: Webster NA
      – PersonEntity:
          Name:
            NameFull: Andrews B
      – PersonEntity:
          Name:
            NameFull: Fosbeary R
      – PersonEntity:
          Name:
            NameFull: Guest P
      – PersonEntity:
          Name:
            NameFull: Irigoyen N
      – PersonEntity:
          Name:
            NameFull: Eleftheriou M
      – PersonEntity:
          Name:
            NameFull: Gozdecka M
      – PersonEntity:
          Name:
            NameFull: Dias JML
      – PersonEntity:
          Name:
            NameFull: Bannister AJ
      – PersonEntity:
          Name:
            NameFull: Vick B
      – PersonEntity:
          Name:
            NameFull: Jeremias I
      – PersonEntity:
          Name:
            NameFull: Vassiliou GS
      – PersonEntity:
          Name:
            NameFull: Rausch O
      – PersonEntity:
          Name:
            NameFull: Tzelepis K
      – PersonEntity:
          Name:
            NameFull: Kouzarides T
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2021 May
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
            – Type: volume
              Value: 593
            – Type: issue
              Value: 7860
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1