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SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.

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Title: SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.
Authors: Choe JH; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Watchmaker PB; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA., Simic MS; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Gilbert RD; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA., Li AW; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Krasnow NA; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Downey KM; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA., Yu W; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Carrera DA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA., Celli A; Department of Veterans' Affairs Medical Center, University of California, San Francisco, San Francisco, CA 94158, USA., Cho J; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Briones JD; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Duecker JM; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Goretsky YE; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA., Dannenfelser R; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA.; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA., Cardarelli L; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Troyanskaya O; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA.; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA., Sidhu SS; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Roybal KT; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. kole.roybal@ucsf.edu hideho.okada@ucsf.edu wendell.lim@ucsf.edu.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.; Helen Diller Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Okada H; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA. kole.roybal@ucsf.edu hideho.okada@ucsf.edu wendell.lim@ucsf.edu.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94158, USA.; Helen Diller Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Lim WA; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. kole.roybal@ucsf.edu hideho.okada@ucsf.edu wendell.lim@ucsf.edu.; Helen Diller Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA.
Source: Science translational medicine [Sci Transl Med] 2021 Apr 28; Vol. 13 (591).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Choe+JH%22">Choe JH</searchLink>; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Watchmaker+PB%22">Watchmaker PB</searchLink>; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Simic+MS%22">Simic MS</searchLink>; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Gilbert+RD%22">Gilbert RD</searchLink>; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Li+AW%22">Li AW</searchLink>; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Krasnow+NA%22">Krasnow NA</searchLink>; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Downey+KM%22">Downey KM</searchLink>; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Yu+W%22">Yu W</searchLink>; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Carrera+DA%22">Carrera DA</searchLink>; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Celli+A%22">Celli A</searchLink>; Department of Veterans' Affairs Medical Center, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Cho+J%22">Cho J</searchLink>; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Briones+JD%22">Briones JD</searchLink>; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Duecker+JM%22">Duecker JM</searchLink>; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Goretsky+YE%22">Goretsky YE</searchLink>; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Dannenfelser+R%22">Dannenfelser R</searchLink>; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA.; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA.<br /><searchLink fieldCode="AU" term="%22Cardarelli+L%22">Cardarelli L</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.<br /><searchLink fieldCode="AU" term="%22Troyanskaya+O%22">Troyanskaya O</searchLink>; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA.; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA.<br /><searchLink fieldCode="AU" term="%22Sidhu+SS%22">Sidhu SS</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.<br /><searchLink fieldCode="AU" term="%22Roybal+KT%22">Roybal KT</searchLink>; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. kole.roybal@ucsf.edu hideho.okada@ucsf.edu wendell.lim@ucsf.edu.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.; Helen Diller Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Okada+H%22">Okada H</searchLink>; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA. kole.roybal@ucsf.edu hideho.okada@ucsf.edu wendell.lim@ucsf.edu.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94158, USA.; Helen Diller Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Lim+WA%22">Lim WA</searchLink>; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. kole.roybal@ucsf.edu hideho.okada@ucsf.edu wendell.lim@ucsf.edu.; Helen Diller Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA.
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