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Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.

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Bibliographic Details
Title: Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
Authors: Yan NL; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Santos-Martins D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States., Nair R; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Chu A; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States., Johnson KA; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States., Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States., Morgan GJ; Section of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, United States.; The Amyloidosis Center, Boston University School of Medicine, Boston, Massachusetts 02118, United States., Petrassi HM; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States., Kelly JW; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 6273-6299. Date of Electronic Publication: 2021 May 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.1c00339