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Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.

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Title: Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
Authors: Yan NL; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Santos-Martins D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States., Nair R; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States., Chu A; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States., Johnson KA; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States., Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States., Morgan GJ; Section of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, United States.; The Amyloidosis Center, Boston University School of Medicine, Boston, Massachusetts 02118, United States., Petrassi HM; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States., Kelly JW; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 6273-6299. Date of Electronic Publication: 2021 May 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
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  Data: <searchLink fieldCode="AU" term="%22Yan+NL%22">Yan NL</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Santos-Martins+D%22">Santos-Martins D</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Nair+R%22">Nair R</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Chu+A%22">Chu A</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Wilson+IA%22">Wilson IA</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Johnson+KA%22">Johnson KA</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Forli+S%22">Forli S</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Morgan+GJ%22">Morgan GJ</searchLink>; Section of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, United States.; The Amyloidosis Center, Boston University School of Medicine, Boston, Massachusetts 02118, United States.<br /><searchLink fieldCode="AU" term="%22Petrassi+HM%22">Petrassi HM</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Kelly+JW%22">Kelly JW</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 6273-6299. <i>Date of Electronic Publication: </i>2021 May 03.
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  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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        Value: 10.1021/acs.jmedchem.1c00339
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