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Evolution of delayed resistance to immunotherapy in a melanoma responder.

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Title: Evolution of delayed resistance to immunotherapy in a melanoma responder.
Authors: Liu D; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lin JR; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Robitschek EJ; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kasumova GG; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Heyde A; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA., Shi A; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA., Kraya A; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Zhang G; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.; Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Department of Pathology, Duke University School of Medicine, Durham, NC, USA., Moll T; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Frederick DT; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Chen YA; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Wang S; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Schapiro D; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ho LL; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA., Bi K; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Sahu A; Dana-Farber Cancer Institute, Boston, MA, USA., Mei S; Dana-Farber Cancer Institute, Boston, MA, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Miao B; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Sharova T; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Alvarez-Breckenridge C; Department of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Stocking JH; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Kim T; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Fadden R; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Lawrence D; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Hoang MP; Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Cahill DP; Department of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Malehmir M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Nowak MA; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Department of Mathematics, Harvard University, Cambridge, MA, USA., Brastianos PK; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Lian CG; Department of Pathology, Harvard Medical School, Brigham and Woman's Hospital, Boston, MA, USA., Ruppin E; Cancer Data Science Lab, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Izar B; Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translation Immunology, New York, NY, USA., Herlyn M; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA., Van Allen EM; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Nathanson K; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Basser Center for BRCA, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Flaherty KT; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Sullivan RJ; Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Kellis M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA., Sorger PK; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Cambridge, MA, USA., Boland GM; Broad Institute of Harvard and MIT, Cambridge, MA, USA. gmboland@mgh.harvard.edu.; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA. gmboland@mgh.harvard.edu.
Source: Nature medicine [Nat Med] 2021 Jun; Vol. 27 (6), pp. 985-992. Date of Electronic Publication: 2021 May 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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Broad Institute of Harvard and MIT, Cambridge, MA, USA. gmboland@mgh.harvard.edu.; Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA. gmboland@mgh.harvard.edu.
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