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A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801.

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Title: A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801.
Authors: Morris PJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA. Electronic address: patrick.morris@nih.gov., Burke RD; Covance Laboratories, Inc., Madison, WI 53704, USA., Sharma AK; Covance Laboratories, Inc., Madison, WI 53704, USA., Lynch DC; Covance Laboratories, Inc., Madison, WI 53704, USA., Lemke-Boutcher LE; Covance Laboratories, Inc., Greenfield, IN 46140, USA., Mathew S; Division of Pharmacology/Toxicology Neuroscience, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Elayan I; Division of Pharmacology/Toxicology Neuroscience, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Rao DB; Division of Pharmacology/Toxicology Neuroscience, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Gould TD; Departments of Psychiatry, Pharmacology, and Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Veterans Affairs Maryland Health Care System, Baltimore, MD, USA., Zarate CA Jr; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA., Zanos P; Department of Psychiatry, Pharmacology, and Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Moaddel R; Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Source: Neurotoxicology and teratology [Neurotoxicol Teratol] 2021 Sep-Oct; Vol. 87, pp. 106993. Date of Electronic Publication: 2021 May 01.
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
Journal Info: Publisher: Pergamon Press Country of Publication: United States NLM ID: 8709538 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9738 (Electronic) Linking ISSN: 08920362 NLM ISO Abbreviation: Neurotoxicol Teratol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Morris+PJ%22">Morris PJ</searchLink>; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA. Electronic address: patrick.morris@nih.gov.<br /><searchLink fieldCode="AU" term="%22Burke+RD%22">Burke RD</searchLink>; Covance Laboratories, Inc., Madison, WI 53704, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+AK%22">Sharma AK</searchLink>; Covance Laboratories, Inc., Madison, WI 53704, USA.<br /><searchLink fieldCode="AU" term="%22Lynch+DC%22">Lynch DC</searchLink>; Covance Laboratories, Inc., Madison, WI 53704, USA.<br /><searchLink fieldCode="AU" term="%22Lemke-Boutcher+LE%22">Lemke-Boutcher LE</searchLink>; Covance Laboratories, Inc., Greenfield, IN 46140, USA.<br /><searchLink fieldCode="AU" term="%22Mathew+S%22">Mathew S</searchLink>; Division of Pharmacology/Toxicology Neuroscience, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Elayan+I%22">Elayan I</searchLink>; Division of Pharmacology/Toxicology Neuroscience, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rao+DB%22">Rao DB</searchLink>; Division of Pharmacology/Toxicology Neuroscience, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gould+TD%22">Gould TD</searchLink>; Departments of Psychiatry, Pharmacology, and Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zarate+CA+Jr%22">Zarate CA Jr</searchLink>; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Zanos+P%22">Zanos P</searchLink>; Department of Psychiatry, Pharmacology, and Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.<br /><searchLink fieldCode="AU" term="%22Moaddel+R%22">Moaddel R</searchLink>; Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+CJ%22">Thomas CJ</searchLink>; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
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  Data: <searchLink fieldCode="JN" term="%228709538%22">Neurotoxicology and teratology</searchLink> [Neurotoxicol Teratol] 2021 Sep-Oct; Vol. 87, pp. 106993. <i>Date of Electronic Publication: </i>2021 May 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Pergamon+Press%22">Pergamon Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8709538 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-9738 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208920362%22">08920362 </searchLink><i>NLM ISO Abbreviation: </i>Neurotoxicol Teratol <i>Subsets: </i>MEDLINE
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