A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801.
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| Title: | A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801. |
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| Authors: | Morris PJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA. Electronic address: patrick.morris@nih.gov., Burke RD; Covance Laboratories, Inc., Madison, WI 53704, USA., Sharma AK; Covance Laboratories, Inc., Madison, WI 53704, USA., Lynch DC; Covance Laboratories, Inc., Madison, WI 53704, USA., Lemke-Boutcher LE; Covance Laboratories, Inc., Greenfield, IN 46140, USA., Mathew S; Division of Pharmacology/Toxicology Neuroscience, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Elayan I; Division of Pharmacology/Toxicology Neuroscience, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Rao DB; Division of Pharmacology/Toxicology Neuroscience, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Gould TD; Departments of Psychiatry, Pharmacology, and Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Veterans Affairs Maryland Health Care System, Baltimore, MD, USA., Zarate CA Jr; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA., Zanos P; Department of Psychiatry, Pharmacology, and Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Moaddel R; Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA. |
| Source: | Neurotoxicology and teratology [Neurotoxicol Teratol] 2021 Sep-Oct; Vol. 87, pp. 106993. Date of Electronic Publication: 2021 May 01. |
| Publication Type: | Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural |
| Journal Info: | Publisher: Pergamon Press Country of Publication: United States NLM ID: 8709538 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9738 (Electronic) Linking ISSN: 08920362 NLM ISO Abbreviation: Neurotoxicol Teratol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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