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Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial.

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Title: Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial.
Authors: Bégin P; Section of Allergy, Immunology and Rheumatology, Department of Pediatrics, CHU Sainte-Justine, Montreal, Quebec, Canada.; Department of Medicine, CHUM, Université de Montréal, Montreal, Quebec, Canada., Callum J; Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Heddle NM; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada., Cook R; Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada., Zeller MP; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada.; Canadian Blood Services, Ottawa, Ontario, Canada., Tinmouth A; Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Centre for Transfusion Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Canadian Blood Services, Ottawa, Ontario, Canada., Fergusson DA; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Adjunct Scientist, Canadian Blood Services, Ottawa, Ontario, Canada., Cushing MM; Transfusion Medicine and Cellular Therapy, NewYork-Presbyterian, New York, NY, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Glesby MJ; Division of Infectious Diseases, Weill Cornell Medical College, Weill Cornell Medicine, New York, NY, USA., Chassé M; Department of Medicine (Critical Care), University of Montreal Health Centre (CHUM), Montreal, Quebec, Canada.; Department of Medicine, University of Montreal, Montreal, Quebec, Canada., Devine DV; Canadian Blood Services, Ottawa, Ontario, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Ottawa, Ontario, Canada., Robitalle N; Héma-Québec, Saint-Laurent, Montreal, Canada.; Division of Hematology and Oncology, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Ottawa, Ontario, Canada., Bazin R; Medical Affairs and Innovation, Héma-Québec, Saint-Laurent, Montreal, Canada., Shehata N; Departments of Medicine, Laboratory Medicine and Pathobiology, Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Division of Hematology, Mount Sinai Hospital, Toronto, Ontario, Canada.; Canadian Blood Services, Toronto, Ontario, Canada., Finzi A; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.; CHUM Research Center, Montreal, Quebec, Canada., McGeer A; Department of Microbiology, Sinai Health System, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Scales DC; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Medicine, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada., Schwartz L; Department of Health Research Methods, Evidence & Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada., Turgeon AF; Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Faculty of Medicine, Université Laval, Quebec, Quebec, Canada.; CHU de Québec - Université Laval Research Centre, Population Health and Optimal Health Practices Research Unit, Trauma - Emergency - Critical Care Medicine, Université Laval, Quebec, Quebec, Canada., Zarychanski R; Department of Internal Medicine, Sections of Hematology/Medical Oncology and Critical Care, University of Manitoba, Winnipeg, Manitoba, Canada., Daneman N; Department of Medicine, Division of Infectious Diseases, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada., Carl R; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada., Amorim L; Hemorio, Rio de Janeiro, Brazil., Gabe C; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada., Ellis M; Hematology Institute and Blood Bank, Meir Medical Center, Tel Aviv, Israël.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israël., Sachais BS; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.; New York Blood Center Enterprises, New York, NY, USA., Loftsgard KC; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada., Jamula E; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada., Carruthers J; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada., Duncan J; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada., Lucier K; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada., Li N; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada.; Department of Computing and Software, McMaster University, Hamilton, Ontario, Canada.; Department of Community Health Sciences, University of Calgary, Hamilton, Ontario, Canada., Liu Y; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada., Armali C; Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Kron A; Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Modi D; Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Auclair MC; Clinical Research Department, Centre de recherche du CHU Sainte-Justine, Centre Hospitalier Universitaire Sainte-Justine Centre, Montreal, Canada., Cerro S; Clinical Research Department, Centre de recherche du CHU Sainte-Justine, Centre Hospitalier Universitaire Sainte-Justine Centre, Montreal, Canada., Avram M; Clinical Research Department, Centre de recherche du CHU Sainte-Justine, Centre Hospitalier Universitaire Sainte-Justine Centre, Montreal, Canada., Arnold DM; Department of Medicine, McMaster University, Hamilton, Ontario, Canada. arnold@mcmaster.ca.; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada. arnold@mcmaster.ca.
Source: Trials [Trials] 2021 May 04; Vol. 22 (1), pp. 323. Date of Electronic Publication: 2021 May 04.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial.
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  Data: <searchLink fieldCode="AU" term="%22Bégin+P%22">Bégin P</searchLink>; Section of Allergy, Immunology and Rheumatology, Department of Pediatrics, CHU Sainte-Justine, Montreal, Quebec, Canada.; Department of Medicine, CHUM, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Callum+J%22">Callum J</searchLink>; Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Heddle+NM%22">Heddle NM</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Cook+R%22">Cook R</searchLink>; Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zeller+MP%22">Zeller MP</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada.; Canadian Blood Services, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tinmouth+A%22">Tinmouth A</searchLink>; Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Centre for Transfusion Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Canadian Blood Services, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Fergusson+DA%22">Fergusson DA</searchLink>; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Adjunct Scientist, Canadian Blood Services, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Cushing+MM%22">Cushing MM</searchLink>; Transfusion Medicine and Cellular Therapy, NewYork-Presbyterian, New York, NY, USA.; 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Medical Affairs and Innovation, Héma-Québec, Saint-Laurent, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Shehata+N%22">Shehata N</searchLink>; Departments of Medicine, Laboratory Medicine and Pathobiology, Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Division of Hematology, Mount Sinai Hospital, Toronto, Ontario, Canada.; Canadian Blood Services, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Finzi+A%22">Finzi A</searchLink>; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.; CHUM Research Center, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22McGeer+A%22">McGeer A</searchLink>; Department of Microbiology, Sinai Health System, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Scales+DC%22">Scales DC</searchLink>; 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Department of Medicine, Division of Infectious Diseases, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Carl+R%22">Carl R</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Amorim+L%22">Amorim L</searchLink>; Hemorio, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Gabe+C%22">Gabe C</searchLink>; McMaster Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ellis+M%22">Ellis M</searchLink>; Hematology Institute and Blood Bank, Meir Medical Center, Tel Aviv, Israël.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israël.<br /><searchLink fieldCode="AU" term="%22Sachais+BS%22">Sachais BS</searchLink>; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.; 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