The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis.
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| Title: | The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis. |
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| Authors: | Sato M; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Department of Cardiovascular Medicine, School of Medicine, Saga University, Saga, Japan.; Division of Kumamoto Mouse Clinic (KMC), Institute of Resource Developmental and Analysis (IRDA), Kumamoto University, Kumamoto, Japan., Kadomatsu T; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Miyata K; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Department of Immunity, Allergy, and Vascular Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Warren JS; Division of Kumamoto Mouse Clinic (KMC), Institute of Resource Developmental and Analysis (IRDA), Kumamoto University, Kumamoto, Japan.; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Tian Z; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Zhu S; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Horiguchi H; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Department of Aging and Geriatric Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Makaju A; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA., Bakhtina A; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA., Morinaga J; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Sugizaki T; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Hirashima K; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Yoshinobu K; Division of Bioinformatics, Institute of Resource Developmental and Analysis (IRDA), Kumamoto University, Kumamoto, Japan., Imasaka M; Division of Developmental Genetics, Institute of Resource Developmental and Analysis (IRDA), Kumamoto University, Kumamoto, Japan., Araki M; Division of Bioinformatics, Institute of Resource Developmental and Analysis (IRDA), Kumamoto University, Kumamoto, Japan., Komohara Y; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Wakayama T; Department of Histology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Nakagawa S; RNA Biology Laboratory, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan., Franklin S; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Biochemistry, University of Utah, Salt Lake City, UT, USA., Node K; Department of Cardiovascular Medicine, School of Medicine, Saga University, Saga, Japan., Araki K; Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Division of Developmental Genetics, Institute of Resource Developmental and Analysis (IRDA), Kumamoto University, Kumamoto, Japan., Oike Y; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp.; Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp.; Department of Aging and Geriatric Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp. |
| Source: | Nature communications [Nat Commun] 2021 May 05; Vol. 12 (1), pp. 2529. Date of Electronic Publication: 2021 May 05. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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