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Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images.

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Title: Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images.
Authors: Currant H; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, United Kingdom., Hysi P; School of Life Course Sciences, Section of Ophthalmology, King's College London, London, United Kingdom.; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom., Fitzgerald TW; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, United Kingdom., Gharahkhani P; Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Bonnemaijer PWM; Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; The Rotterdam Eye Hospital, Rotterdam, The Netherlands., Senabouth A; Garvan Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, Australia., Hewitt AW; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Tasmania, Australia.; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia., Atan D; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; Bristol Eye Hospital, University Hospitals Bristol & Weston NHS Foundation Trust, Bristol, United Kingdom., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Charng J; Centre for Ophthalmology and Visual Science, Lions Eye Institute, The University of Western Australia, Perth, Australia., Choquet H; Kaiser Permanente Northern California Division of Research, Oakland, California, United States of America., Craig J; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia., Khaw PT; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom., Klaver CCW; Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Ophthalmology Radboud University Medical Center, Nijmegen, The Netherlands.; Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland., Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Ong JS; Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Pasquale LR; Eye and Vision Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Reisman CA; Topcon Healthcare Solutions R&D, Oakland, New Jersey, United States of America., Daniszewski M; Department of Anatomy and Physiology, The University of Melbourne, Parkville, Australia., Powell JE; Garvan Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, Australia.; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, Australia., Pébay A; Department of Anatomy and Physiology, The University of Melbourne, Parkville, Australia.; Department of Surgery, The University of Melbourne, Parkville, Australia., Simcoe MJ; Department of Ophthalmology, Kings College London, London, United Kingdom.; Institute of Ophthalmology, University College London, London, United Kingdom., Thiadens AAHJ; Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands., van Duijn CM; Nuffield Department Of Population Health, University of Oxford, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Oxford, United Kingdom., Yazar S; Garvan-Weizmann Centre for Single Cell Genomics, Garvan Institute of Medical Research, Sydney, Australia., Jorgenson E; Kaiser Permanente Northern California Division of Research, Oakland, California, United States of America., MacGregor S; Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Hammond CJ; School of Life Course Sciences, Section of Ophthalmology, King's College London, London, United Kingdom., Mackey DA; Centre for Ophthalmology and Visual Science, Lions Eye Institute, The University of Western Australia, Perth, Australia., Wiggs JL; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, United States of America., Foster PJ; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom., Patel PJ; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom., Birney E; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, United Kingdom., Khawaja AP; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.
Corporate Authors: UK Biobank Eye and Vision Consortium, International Glaucoma Genetics Consortium
Source: PLoS genetics [PLoS Genet] 2021 May 12; Vol. 17 (5), pp. e1009497. Date of Electronic Publication: 2021 May 12 (Print Publication: 2021).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images.
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  Data: <searchLink fieldCode="AU" term="%22Currant+H%22">Currant H</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hysi+P%22">Hysi P</searchLink>; School of Life Course Sciences, Section of Ophthalmology, King's College London, London, United Kingdom.; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+TW%22">Fitzgerald TW</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gharahkhani+P%22">Gharahkhani P</searchLink>; Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Bonnemaijer+PWM%22">Bonnemaijer PWM</searchLink>; Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; The Rotterdam Eye Hospital, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Senabouth+A%22">Senabouth A</searchLink>; Garvan Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, Australia.<br /><searchLink fieldCode="AU" term="%22Hewitt+AW%22">Hewitt AW</searchLink>; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Tasmania, Australia.; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Atan+D%22">Atan D</searchLink>; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; Bristol Eye Hospital, University Hospitals Bristol & Weston NHS Foundation Trust, Bristol, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Aung+T%22">Aung T</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Charng+J%22">Charng J</searchLink>; Centre for Ophthalmology and Visual Science, Lions Eye Institute, The University of Western Australia, Perth, Australia.<br /><searchLink fieldCode="AU" term="%22Choquet+H%22">Choquet H</searchLink>; Kaiser Permanente Northern California Division of Research, Oakland, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Craig+J%22">Craig J</searchLink>; Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Australia.<br /><searchLink fieldCode="AU" term="%22Khaw+PT%22">Khaw PT</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Klaver+CCW%22">Klaver CCW</searchLink>; Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Ophthalmology Radboud University Medical Center, Nijmegen, The Netherlands.; Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kubo+M%22">Kubo M</searchLink>; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Ong+JS%22">Ong JS</searchLink>; Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Pasquale+LR%22">Pasquale LR</searchLink>; Eye and Vision Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Reisman+CA%22">Reisman CA</searchLink>; Topcon Healthcare Solutions R&D, Oakland, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Daniszewski+M%22">Daniszewski M</searchLink>; Department of Anatomy and Physiology, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Powell+JE%22">Powell JE</searchLink>; Garvan Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, Australia.; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Pébay+A%22">Pébay A</searchLink>; Department of Anatomy and Physiology, The University of Melbourne, Parkville, Australia.; Department of Surgery, The University of Melbourne, Parkville, Australia.<br /><searchLink fieldCode="AU" term="%22Simcoe+MJ%22">Simcoe MJ</searchLink>; Department of Ophthalmology, Kings College London, London, United Kingdom.; Institute of Ophthalmology, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Thiadens+AAHJ%22">Thiadens AAHJ</searchLink>; Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Duijn+CM%22">van Duijn CM</searchLink>; Nuffield Department Of Population Health, University of Oxford, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Yazar+S%22">Yazar S</searchLink>; Garvan-Weizmann Centre for Single Cell Genomics, Garvan Institute of Medical Research, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Jorgenson+E%22">Jorgenson E</searchLink>; Kaiser Permanente Northern California Division of Research, Oakland, California, United States of America.<br /><searchLink fieldCode="AU" term="%22MacGregor+S%22">MacGregor S</searchLink>; Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Hammond+CJ%22">Hammond CJ</searchLink>; School of Life Course Sciences, Section of Ophthalmology, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mackey+DA%22">Mackey DA</searchLink>; Centre for Ophthalmology and Visual Science, Lions Eye Institute, The University of Western Australia, Perth, Australia.<br /><searchLink fieldCode="AU" term="%22Wiggs+JL%22">Wiggs JL</searchLink>; Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Foster+PJ%22">Foster PJ</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Patel+PJ%22">Patel PJ</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Birney+E%22">Birney E</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Khawaja+AP%22">Khawaja AP</searchLink>; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.
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