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An aged immune system drives senescence and ageing of solid organs.

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Title: An aged immune system drives senescence and ageing of solid organs.
Authors: Yousefzadeh MJ; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Flores RR; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Schmiechen ZC; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Brooks RW; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Trussoni CE; Division of Gastroenterology, Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN, USA., Cui Y; Department of Chemistry, University of California Riverside, Riverside, CA, USA., Angelini L; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Lee KA; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., McGowan SJ; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Burrack AL; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Wang D; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Dong Q; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Lu A; Department of Orthopedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Sano T; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., O'Kelly RD; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., McGuckian CA; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Kato JI; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Bank MP; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Wade EA; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Pillai SPS; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Klug J; Department of Comparative Medicine, University of Washington, Seattle, WA, USA., Ladiges WC; Department of Comparative Medicine, University of Washington, Seattle, WA, USA., Burd CE; Departments of Molecular Genetics and Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA., Lewis SE; Department of Physiology & Pharmacology, West Virginia University, Morgantown, WV, USA., LaRusso NF; Division of Gastroenterology, Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN, USA., Vo NV; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Wang Y; Department of Chemistry, University of California Riverside, Riverside, CA, USA., Kelley EE; Department of Physiology & Pharmacology, West Virginia University, Morgantown, WV, USA., Huard J; Department of Orthopedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Stromnes IM; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA., Robbins PD; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu., Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA. lniedern@umn.edu.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. lniedern@umn.edu.
Source: Nature [Nature] 2021 Jun; Vol. 594 (7861), pp. 100-105. Date of Electronic Publication: 2021 May 12.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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