Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma.

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Title: Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma.
Authors: Xiao L; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Somers K; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Murray J; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Pandher R; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Karsa M; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Ronca E; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Bongers A; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Terry R; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Ehteda A; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Gamble LD; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Issaeva N; Department of Otolaryngology/Head and Neck Surgery, Department of Pathology and Lab Medicine, Lineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, North Carolina., Leonova KI; Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York., O'Connor A; Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia., Mayoh C; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Venkat P; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Quek H; Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Brand J; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Kusuma FK; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Pettitt JA; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Mosmann E; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Kearns A; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Eden G; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Alfred S; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Allan S; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Zhai L; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Kamili A; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Gifford AJ; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Carter DR; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia.; School of Biomedical Engineering, University of Technology Sydney, Australia., Henderson MJ; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Fletcher JI; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Marshall G; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia., Johnstone RW; Immune Defence Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Cesare AJ; Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia., Ziegler DS; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia., Gudkov AV; Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York., Gurova KV; Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York., Norris MD; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia. mhaber@ccia.unsw.edu.au mnorris@ccia.unsw.edu.au.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia.; University of New South Wales Centre for Childhood Cancer Research, Sydney, Australia., Haber M; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia. mhaber@ccia.unsw.edu.au mnorris@ccia.unsw.edu.au.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Aug 01; Vol. 27 (15), pp. 4338-4352. Date of Electronic Publication: 2021 May 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-20-2357