The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe-S cluster in DNA polymerase δ. - Kiktev DA; Dominska M; Zhang T; Dahl J; Stepchenkova EI; Mieczkowski P; Burgers PM; Lujan S; Burkholder A; Kunkel TA; Petes TD (Nucleic acids research, 2021)