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Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling.

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Title: Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling.
Authors: Li X; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Chandra D; Biologics Process Research & Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Letarte S; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Adam GC; Quantitative Biosciences, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Welch J; Biologics Analytical Research & Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Yang RS; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Rivera S; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Bodea S; Chemical Biology, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Dow A; Biologics Analytical Research & Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Chi A; Chemical Biology, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Strulson CA; Biologics Analytical Research & Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Richardson DD; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
Source: Analytical chemistry [Anal Chem] 2021 Jun 15; Vol. 93 (23), pp. 8161-8169. Date of Electronic Publication: 2021 May 25.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling.
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  Data: <searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Chandra+D%22">Chandra D</searchLink>; Biologics Process Research & Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Letarte+S%22">Letarte S</searchLink>; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Adam+GC%22">Adam GC</searchLink>; Quantitative Biosciences, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Welch+J%22">Welch J</searchLink>; Biologics Analytical Research & Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Yang+RS%22">Yang RS</searchLink>; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Rivera+S%22">Rivera S</searchLink>; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Bodea+S%22">Bodea S</searchLink>; Chemical Biology, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Dow+A%22">Dow A</searchLink>; Biologics Analytical Research & Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Chi+A%22">Chi A</searchLink>; Chemical Biology, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Strulson+CA%22">Strulson CA</searchLink>; Biologics Analytical Research & Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Richardson+DD%22">Richardson DD</searchLink>; Analytical Research & Development Mass Spectrometry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
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  Data: <searchLink fieldCode="JN" term="%220370536%22">Analytical chemistry</searchLink> [Anal Chem] 2021 Jun 15; Vol. 93 (23), pp. 8161-8169. <i>Date of Electronic Publication: </i>2021 May 25.
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