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Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark of Multisystem Inflammatory Syndrome in Children.

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Title: Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark of Multisystem Inflammatory Syndrome in Children.
Authors: Moreews M; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Le Gouge K; Sorbonne Université, UPMC Univ Paris 06, INSERM UMRS 959, Immunology Immunopathology-Immunotherapy (i3), Paris, France., Khaldi-Plassart S; (RAISE), France; Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon.; National Referee Centre for Rheumatic and AutoImmune and Systemic diseases in children., Pescarmona R; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; National Referee Centre for Rheumatic and AutoImmune and Systemic diseases in children.; Immunology Laboratory, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite., Mathieu AL; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France. alexandre.belot@chu-lyon.fr., Malcus C; Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437 Lyon, France.; EA 7426 'Pathophysiology of Injury-Induced Immunosuppression' (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux), Joint Research Unit HCL-bioMérieux, 69003, Lyon, France., Djebali S; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Bellomo A; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Dauwalder O; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Hospices Civils de Lyon, F-69004, Lyon, France., Perret M; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Immunology Laboratory, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite., Villard M; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Immunology Laboratory, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite., Chopin E; Cellular Biotechnology Department and Biobank, Hospices Civils de Lyon, Lyon, France., Rouvet I; Cellular Biotechnology Department and Biobank, Hospices Civils de Lyon, Lyon, France., Vandenesh F; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Hospices Civils de Lyon, F-69004, Lyon, France., Dupieux C; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Hospices Civils de Lyon, F-69004, Lyon, France., Pouyau R; Réanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France., Teyssedre S; Réanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France., Guerder M; Réanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France., Louazon T; Service de pédiatrie, Centre Hospitalier de Valence, France., Moulin-Zinsch A; Unité medico-chirurgicale des cardiopathies congénitales, hôpital Louis-Pradel, hospices civils de Lyon, 69677 Bron, France., Duperril M; Pediatric intensive care unit - University hospital of Saint-Étienne, France., Patural H; Pediatric intensive care unit - University hospital of Saint-Étienne, France.; U1059 INSERM - SAINBIOSE - DVH - Université de Saint-Étienne - 42055, France., Giovannini-Chami L; Pediatric Pulmonology and Allergology Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.; Université Côte d'Azur, France., Portefaix A; Center of Clinical Investigation, Lyon University Hospital, Bron, France., Kassai B; Center of Clinical Investigation, Lyon University Hospital, Bron, France., Venet F; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437 Lyon, France., Monneret G; Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437 Lyon, France.; EA 7426 'Pathophysiology of Injury-Induced Immunosuppression' (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux), Joint Research Unit HCL-bioMérieux, 69003, Lyon, France., Lombard C; Immunology Laboratory, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite., Flodrops H; Service de Pédiatrie, Groupe Hospitalier Sud Réunion, CHU de La Réunion, Saint Pierre, La Réunion, France., De Guillebon JM; Service de Néphrologie, Rhumatologie pédiatrique, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France., Bajolle F; Hôpital Necker Enfants Malades, Centre de référence M3C, AP-HP, Paris, France., Launay V; Urgences pédiatriques, Hôpital femme Mère Enfant, Hospices Civils de Lyon, Bron, France., Bastard P; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France., Zhang SY; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Dubois V; EFS Auvergne Rhône Alpes, laboratoire Histocompatibilité, 111, rue Elisée-Reclus, 69150 Décines, France., Thaunat O; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; EFS Auvergne Rhône Alpes, laboratoire Histocompatibilité, 111, rue Elisée-Reclus, 69150 Décines, France.; Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot University Hospital, Lyon, France.; Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France., Richard JC; Médecine Intensive-Réanimation, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.; Lyon University, France., Mezidi M; Médecine Intensive-Réanimation, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.; Lyon University, France., Allatif O; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Saker K; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France., Dreux M; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Abel L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, NY, USA., Marvel J; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Trouillet-Assant S; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France., Klatzmann D; Sorbonne Université, UPMC Univ Paris 06, INSERM UMRS 959, Immunology Immunopathology-Immunotherapy (i3), Paris, France.; Assistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Biotherapy and Département Hospitalo-Universitaire Inflammation-Immunopathology-Biotherapy (i2B), Paris, France., Walzer T; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Mariotti-Ferrandiz E; Sorbonne Université, UPMC Univ Paris 06, INSERM UMRS 959, Immunology Immunopathology-Immunotherapy (i3), Paris, France.; Assistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Biotherapy and Département Hospitalo-Universitaire Inflammation-Immunopathology-Biotherapy (i2B), Paris, France., Javouhey E; EA 7426 'Pathophysiology of Injury-Induced Immunosuppression' (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux), Joint Research Unit HCL-bioMérieux, 69003, Lyon, France.; Réanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France., Belot A; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France. alexandre.belot@chu-lyon.fr.; Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437 Lyon, France.
Source: Science immunology [Sci Immunol] 2021 May 25; Vol. 6 (59).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Polyclonal expansion of TCR Vbeta 21.3<superscript>+</superscript> CD4<superscript>+</superscript> and CD8<superscript>+</superscript> T cells is a hallmark of Multisystem Inflammatory Syndrome in Children.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Moreews+M%22">Moreews M</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Le+Gouge+K%22">Le Gouge K</searchLink>; Sorbonne Université, UPMC Univ Paris 06, INSERM UMRS 959, Immunology Immunopathology-Immunotherapy (i3), Paris, France.<br /><searchLink fieldCode="AU" term="%22Khaldi-Plassart+S%22">Khaldi-Plassart S</searchLink>; (RAISE), France; Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon.; National Referee Centre for Rheumatic and AutoImmune and Systemic diseases in children.<br /><searchLink fieldCode="AU" term="%22Pescarmona+R%22">Pescarmona R</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; National Referee Centre for Rheumatic and AutoImmune and Systemic diseases in children.; Immunology Laboratory, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite.<br /><searchLink fieldCode="AU" term="%22Mathieu+AL%22">Mathieu AL</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France. alexandre.belot@chu-lyon.fr.<br /><searchLink fieldCode="AU" term="%22Malcus+C%22">Malcus C</searchLink>; Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437 Lyon, France.; EA 7426 'Pathophysiology of Injury-Induced Immunosuppression' (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux), Joint Research Unit HCL-bioMérieux, 69003, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Djebali+S%22">Djebali S</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Bellomo+A%22">Bellomo A</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Dauwalder+O%22">Dauwalder O</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Hospices Civils de Lyon, F-69004, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Perret+M%22">Perret M</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Immunology Laboratory, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite.<br /><searchLink fieldCode="AU" term="%22Villard+M%22">Villard M</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Immunology Laboratory, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite.<br /><searchLink fieldCode="AU" term="%22Chopin+E%22">Chopin E</searchLink>; Cellular Biotechnology Department and Biobank, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Rouvet+I%22">Rouvet I</searchLink>; Cellular Biotechnology Department and Biobank, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Vandenesh+F%22">Vandenesh F</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Hospices Civils de Lyon, F-69004, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Dupieux+C%22">Dupieux C</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Hospices Civils de Lyon, F-69004, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Pouyau+R%22">Pouyau R</searchLink>; Réanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France.<br /><searchLink fieldCode="AU" term="%22Teyssedre+S%22">Teyssedre S</searchLink>; Réanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France.<br /><searchLink fieldCode="AU" term="%22Guerder+M%22">Guerder M</searchLink>; Réanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France.<br /><searchLink fieldCode="AU" term="%22Louazon+T%22">Louazon T</searchLink>; Service de pédiatrie, Centre Hospitalier de Valence, France.<br /><searchLink fieldCode="AU" term="%22Moulin-Zinsch+A%22">Moulin-Zinsch A</searchLink>; Unité medico-chirurgicale des cardiopathies congénitales, hôpital Louis-Pradel, hospices civils de Lyon, 69677 Bron, France.<br /><searchLink fieldCode="AU" term="%22Duperril+M%22">Duperril M</searchLink>; Pediatric intensive care unit - University hospital of Saint-Étienne, France.<br /><searchLink fieldCode="AU" term="%22Patural+H%22">Patural H</searchLink>; Pediatric intensive care unit - University hospital of Saint-Étienne, France.; U1059 INSERM - SAINBIOSE - DVH - Université de Saint-Étienne - 42055, France.<br /><searchLink fieldCode="AU" term="%22Giovannini-Chami+L%22">Giovannini-Chami L</searchLink>; Pediatric Pulmonology and Allergology Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.; Université Côte d'Azur, France.<br /><searchLink fieldCode="AU" term="%22Portefaix+A%22">Portefaix A</searchLink>; Center of Clinical Investigation, Lyon University Hospital, Bron, France.<br /><searchLink fieldCode="AU" term="%22Kassai+B%22">Kassai B</searchLink>; Center of Clinical Investigation, Lyon University Hospital, Bron, France.<br /><searchLink fieldCode="AU" term="%22Venet+F%22">Venet F</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437 Lyon, France.<br /><searchLink fieldCode="AU" term="%22Monneret+G%22">Monneret G</searchLink>; Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437 Lyon, France.; EA 7426 'Pathophysiology of Injury-Induced Immunosuppression' (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux), Joint Research Unit HCL-bioMérieux, 69003, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Lombard+C%22">Lombard C</searchLink>; Immunology Laboratory, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite.<br /><searchLink fieldCode="AU" term="%22Flodrops+H%22">Flodrops H</searchLink>; Service de Pédiatrie, Groupe Hospitalier Sud Réunion, CHU de La Réunion, Saint Pierre, La Réunion, France.<br /><searchLink fieldCode="AU" term="%22De+Guillebon+JM%22">De Guillebon JM</searchLink>; Service de Néphrologie, Rhumatologie pédiatrique, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.<br /><searchLink fieldCode="AU" term="%22Bajolle+F%22">Bajolle F</searchLink>; Hôpital Necker Enfants Malades, Centre de référence M3C, AP-HP, Paris, France.<br /><searchLink fieldCode="AU" term="%22Launay+V%22">Launay V</searchLink>; Urgences pédiatriques, Hôpital femme Mère Enfant, Hospices Civils de Lyon, Bron, France.<br /><searchLink fieldCode="AU" term="%22Bastard+P%22">Bastard P</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Zhang+SY%22">Zhang SY</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dubois+V%22">Dubois V</searchLink>; EFS Auvergne Rhône Alpes, laboratoire Histocompatibilité, 111, rue Elisée-Reclus, 69150 Décines, France.<br /><searchLink fieldCode="AU" term="%22Thaunat+O%22">Thaunat O</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; EFS Auvergne Rhône Alpes, laboratoire Histocompatibilité, 111, rue Elisée-Reclus, 69150 Décines, France.; Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot University Hospital, Lyon, France.; Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Richard+JC%22">Richard JC</searchLink>; Médecine Intensive-Réanimation, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.; Lyon University, France.<br /><searchLink fieldCode="AU" term="%22Mezidi+M%22">Mezidi M</searchLink>; Médecine Intensive-Réanimation, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.; Lyon University, France.<br /><searchLink fieldCode="AU" term="%22Allatif+O%22">Allatif O</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Saker+K%22">Saker K</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Dreux+M%22">Dreux M</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Abel+L%22">Abel L</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Casanova+JL%22">Casanova JL</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, NY, USA.<br /><searchLink fieldCode="AU" term="%22Marvel+J%22">Marvel J</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Trouillet-Assant+S%22">Trouillet-Assant S</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Klatzmann+D%22">Klatzmann D</searchLink>; Sorbonne Université, UPMC Univ Paris 06, INSERM UMRS 959, Immunology Immunopathology-Immunotherapy (i3), Paris, France.; Assistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Biotherapy and Département Hospitalo-Universitaire Inflammation-Immunopathology-Biotherapy (i2B), Paris, France.<br /><searchLink fieldCode="AU" term="%22Walzer+T%22">Walzer T</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Mariotti-Ferrandiz+E%22">Mariotti-Ferrandiz E</searchLink>; Sorbonne Université, UPMC Univ Paris 06, INSERM UMRS 959, Immunology Immunopathology-Immunotherapy (i3), Paris, France.; Assistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Biotherapy and Département Hospitalo-Universitaire Inflammation-Immunopathology-Biotherapy (i2B), Paris, France.<br /><searchLink fieldCode="AU" term="%22Javouhey+E%22">Javouhey E</searchLink>; EA 7426 'Pathophysiology of Injury-Induced Immunosuppression' (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux), Joint Research Unit HCL-bioMérieux, 69003, Lyon, France.; Réanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France.<br /><searchLink fieldCode="AU" term="%22Belot+A%22">Belot A</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France. alexandre.belot@chu-lyon.fr.; Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437 Lyon, France.
– Name: TitleSource
  Label: Source
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  Data: <searchLink fieldCode="JN" term="%22101688624%22">Science immunology</searchLink> [Sci Immunol] 2021 May 25; Vol. 6 (59).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101688624 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2470-9468 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2224709468%22">24709468 </searchLink><i>NLM ISO Abbreviation: </i>Sci Immunol <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1126/sciimmunol.abh1516
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark of Multisystem Inflammatory Syndrome in Children.
        Type: main
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            – D: 25
              M: 05
              Text: 2021 May 25
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-electronic
              Value: 2470-9468
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            – Type: issue
              Value: 59
          Titles:
            – TitleFull: Science immunology
              Type: main
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