View in EDS PDF Full Text

Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model.

Saved in:
Bibliographic Details
Title: Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model.
Authors: Simovic M; Group Genome Instability in Tumors, German Cancer Research Center, (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Bolkestein M; Group Genome Instability in Tumors, German Cancer Research Center, (DKFZ), Heidelberg, Germany., Moustafa M; Division of Molecular & Translational Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany.; National Center for Radiation Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Heidelberg University Hospital (UKHD) and DKFZ, Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt., Wong JKL; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Division of Molecular Genetics, DKFZ, Heidelberg, Germany., Körber V; Division of Theoretical Systems Biology, DKFZ, Heidelberg, Germany., Benedetto S; Division of Theoretical Systems Biology, DKFZ, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany., Khalid U; Group Genome Instability in Tumors, German Cancer Research Center, (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Schreiber HS; Group Genome Instability in Tumors, German Cancer Research Center, (DKFZ), Heidelberg, Germany.; Faculty of Medicine, Heidelberg University, Heidelberg, Germany., Jugold M; Core Facility, Small Animal Imaging Center, DKFZ, Heidelberg, Germany., Korshunov A; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, DKFZ, Department of Neuropathology, UKHD, Heidelberg, Germany., Hübschmann D; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Computational Oncology Group, Molecular Diagnostics Program at the NCT and DKFZ, Heidelberg, Germany.; Heidelberg Institute for Stem cell Technology and Experimental Medicine, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, UKHD, Heidelberg, Germany., Mack N; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Division of Molecular Genetics, DKFZ, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, UKHD, Heidelberg, Germany.; Hopp Children's Cancer Center, NCT Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany., Brons S; Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany., Wei PC; Brain Mosaicism and Tumorigenesis, DKFZ, Heidelberg, Germany., Breckwoldt MO; Department of Neuroradiology, UKHD, Heidelberg, Germany., Heiland S; Department of Neuroradiology, UKHD, Heidelberg, Germany., Bendszus M; Department of Neuroradiology, UKHD, Heidelberg, Germany., Debus J; Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Department of Radiation Oncology, UKHD, Heidelberg, Germany.; Department of Radiation Oncology, Eberhard-Karls-University Tuebingen, Tübingen, Germany.; Clinical Cooperation Unit Radiation Oncology, DKFZ, Heidelberg, Germany., Höfer T; Division of Theoretical Systems Biology, DKFZ, Heidelberg, Germany., Zapatka M; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Division of Molecular Genetics, DKFZ, Heidelberg, Germany., Kool M; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Hopp Children's Cancer Center, NCT Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Pfister SM; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, UKHD, Heidelberg, Germany.; Hopp Children's Cancer Center, NCT Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany., Abdollahi A; Division of Molecular & Translational Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany.; National Center for Radiation Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Heidelberg University Hospital (UKHD) and DKFZ, Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany., Ernst A; Group Genome Instability in Tumors, German Cancer Research Center, (DKFZ), Heidelberg, Germany.
Source: Neuro-oncology [Neuro Oncol] 2021 Dec 01; Vol. 23 (12), pp. 2028-2041.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 34049392
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Simovic+M%22">Simovic M</searchLink>; Group Genome Instability in Tumors, German Cancer Research Center, (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bolkestein+M%22">Bolkestein M</searchLink>; Group Genome Instability in Tumors, German Cancer Research Center, (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Moustafa+M%22">Moustafa M</searchLink>; Division of Molecular & Translational Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany.; National Center for Radiation Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Heidelberg University Hospital (UKHD) and DKFZ, Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt.<br /><searchLink fieldCode="AU" term="%22Wong+JKL%22">Wong JKL</searchLink>; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Division of Molecular Genetics, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Körber+V%22">Körber V</searchLink>; Division of Theoretical Systems Biology, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Benedetto+S%22">Benedetto S</searchLink>; Division of Theoretical Systems Biology, DKFZ, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Khalid+U%22">Khalid U</searchLink>; Group Genome Instability in Tumors, German Cancer Research Center, (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schreiber+HS%22">Schreiber HS</searchLink>; Group Genome Instability in Tumors, German Cancer Research Center, (DKFZ), Heidelberg, Germany.; Faculty of Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jugold+M%22">Jugold M</searchLink>; Core Facility, Small Animal Imaging Center, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Korshunov+A%22">Korshunov A</searchLink>; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, DKFZ, Department of Neuropathology, UKHD, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hübschmann+D%22">Hübschmann D</searchLink>; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Computational Oncology Group, Molecular Diagnostics Program at the NCT and DKFZ, Heidelberg, Germany.; Heidelberg Institute for Stem cell Technology and Experimental Medicine, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, UKHD, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mack+N%22">Mack N</searchLink>; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Division of Molecular Genetics, DKFZ, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, UKHD, Heidelberg, Germany.; Hopp Children's Cancer Center, NCT Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Brons+S%22">Brons S</searchLink>; Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wei+PC%22">Wei PC</searchLink>; Brain Mosaicism and Tumorigenesis, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Breckwoldt+MO%22">Breckwoldt MO</searchLink>; Department of Neuroradiology, UKHD, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Heiland+S%22">Heiland S</searchLink>; Department of Neuroradiology, UKHD, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bendszus+M%22">Bendszus M</searchLink>; Department of Neuroradiology, UKHD, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Debus+J%22">Debus J</searchLink>; Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Department of Radiation Oncology, UKHD, Heidelberg, Germany.; Department of Radiation Oncology, Eberhard-Karls-University Tuebingen, Tübingen, Germany.; Clinical Cooperation Unit Radiation Oncology, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Höfer+T%22">Höfer T</searchLink>; Division of Theoretical Systems Biology, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zapatka+M%22">Zapatka M</searchLink>; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Division of Molecular Genetics, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kool+M%22">Kool M</searchLink>; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Hopp Children's Cancer Center, NCT Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, UKHD, Heidelberg, Germany.; Hopp Children's Cancer Center, NCT Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Abdollahi+A%22">Abdollahi A</searchLink>; Division of Molecular & Translational Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany.; National Center for Radiation Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Heidelberg University Hospital (UKHD) and DKFZ, Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner Site Heidelberg, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ernst+A%22">Ernst A</searchLink>; Group Genome Instability in Tumors, German Cancer Research Center, (DKFZ), Heidelberg, Germany.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22100887420%22">Neuro-oncology</searchLink> [Neuro Oncol] 2021 Dec 01; Vol. 23 (12), pp. 2028-2041.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100887420 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1523-5866 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215228517%22">15228517 </searchLink><i>NLM ISO Abbreviation: </i>Neuro Oncol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=34049392
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1093/neuonc/noab127
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2028
    Titles:
      – TitleFull: Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Simovic M
      – PersonEntity:
          Name:
            NameFull: Bolkestein M
      – PersonEntity:
          Name:
            NameFull: Moustafa M
      – PersonEntity:
          Name:
            NameFull: Wong JKL
      – PersonEntity:
          Name:
            NameFull: Körber V
      – PersonEntity:
          Name:
            NameFull: Benedetto S
      – PersonEntity:
          Name:
            NameFull: Khalid U
      – PersonEntity:
          Name:
            NameFull: Schreiber HS
      – PersonEntity:
          Name:
            NameFull: Jugold M
      – PersonEntity:
          Name:
            NameFull: Korshunov A
      – PersonEntity:
          Name:
            NameFull: Hübschmann D
      – PersonEntity:
          Name:
            NameFull: Mack N
      – PersonEntity:
          Name:
            NameFull: Brons S
      – PersonEntity:
          Name:
            NameFull: Wei PC
      – PersonEntity:
          Name:
            NameFull: Breckwoldt MO
      – PersonEntity:
          Name:
            NameFull: Heiland S
      – PersonEntity:
          Name:
            NameFull: Bendszus M
      – PersonEntity:
          Name:
            NameFull: Debus J
      – PersonEntity:
          Name:
            NameFull: Höfer T
      – PersonEntity:
          Name:
            NameFull: Zapatka M
      – PersonEntity:
          Name:
            NameFull: Kool M
      – PersonEntity:
          Name:
            NameFull: Pfister SM
      – PersonEntity:
          Name:
            NameFull: Abdollahi A
      – PersonEntity:
          Name:
            NameFull: Ernst A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: 2021 Dec 01
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-electronic
              Value: 1523-5866
          Numbering:
            – Type: volume
              Value: 23
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: Neuro-oncology
              Type: main
ResultId 1