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Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2'-O-methyl gapmer oligonucleotides.

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Title: Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2'-O-methyl gapmer oligonucleotides.
Authors: Valentin R; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Wong C; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Alharbi AS; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.; The Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Turabah 29179, Saudi Arabia., Pradeloux S; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Morros MP; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Lennox KA; Integrated DNA Technologies Inc., Coralville, IA 52241, USA., Ellyard JI; Department of Immunology and Infectious Diseases, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.; Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia., Garcin AJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Ullah TR; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Kusuma GD; Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia., Pépin G; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Li HM; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Pearson JS; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Ferrand J; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Lim R; Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.; Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia., Veedu RN; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Western Australia 6150, Australia.; Perron Institute for Neurological and Translational Science, Perth, Western Australia 6150, Australia., Morand EF; School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria 3168, Australia., Vinuesa CG; Department of Immunology and Infectious Diseases, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.; Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia., Behlke MA; Integrated DNA Technologies Inc., Coralville, IA 52241, USA., Gantier MP; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.
Source: Nucleic acids research [Nucleic Acids Res] 2021 Jun 21; Vol. 49 (11), pp. 6082-6099.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2'-O-methyl gapmer oligonucleotides.
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  Data: <searchLink fieldCode="AU" term="%22Valentin+R%22">Valentin R</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Wong+C%22">Wong C</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Alharbi+AS%22">Alharbi AS</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.; The Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Turabah 29179, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Pradeloux+S%22">Pradeloux S</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Morros+MP%22">Morros MP</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Lennox+KA%22">Lennox KA</searchLink>; Integrated DNA Technologies Inc., Coralville, IA 52241, USA.<br /><searchLink fieldCode="AU" term="%22Ellyard+JI%22">Ellyard JI</searchLink>; Department of Immunology and Infectious Diseases, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.; Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia.<br /><searchLink fieldCode="AU" term="%22Garcin+AJ%22">Garcin AJ</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Ullah+TR%22">Ullah TR</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Kusuma+GD%22">Kusuma GD</searchLink>; Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Pépin+G%22">Pépin G</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Li+HM%22">Li HM</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Pearson+JS%22">Pearson JS</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Ferrand+J%22">Ferrand J</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Lim+R%22">Lim R</searchLink>; Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.; Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Veedu+RN%22">Veedu RN</searchLink>; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Western Australia 6150, Australia.; Perron Institute for Neurological and Translational Science, Perth, Western Australia 6150, Australia.<br /><searchLink fieldCode="AU" term="%22Morand+EF%22">Morand EF</searchLink>; School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria 3168, Australia.<br /><searchLink fieldCode="AU" term="%22Vinuesa+CG%22">Vinuesa CG</searchLink>; Department of Immunology and Infectious Diseases, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.; Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia.<br /><searchLink fieldCode="AU" term="%22Behlke+MA%22">Behlke MA</searchLink>; Integrated DNA Technologies Inc., Coralville, IA 52241, USA.<br /><searchLink fieldCode="AU" term="%22Gantier+MP%22">Gantier MP</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.
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