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Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants.

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Title: Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants.
Authors: Ku Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Xie X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA., Hinton PR; IGM Biosciences, Mountain View, CA, USA., Liu X; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA., Ye X; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Muruato AE; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA., Ng DC; IGM Biosciences, Mountain View, CA, USA., Biswas S; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA., Zou J; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA., Liu Y; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA., Pandya D; IGM Biosciences, Mountain View, CA, USA., Menachery VD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA., Rahman S; IGM Biosciences, Mountain View, CA, USA., Cao YA; IGM Biosciences, Mountain View, CA, USA., Deng H; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Xiong W; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Carlin KB; IGM Biosciences, Mountain View, CA, USA., Liu J; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Su H; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Haanes EJ; IGM Biosciences, Mountain View, CA, USA., Keyt BA; IGM Biosciences, Mountain View, CA, USA. bkeyt@igmbio.com., Zhang N; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA. Ningyan.Zhang@uth.tmc.edu., Carroll SF; IGM Biosciences, Mountain View, CA, USA. scarroll@igmbio.com., Shi PY; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu.; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu.; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu.; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu., An Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA. Zhiqiang.An@uth.tmc.edu.
Source: Nature [Nature] 2021 Jul; Vol. 595 (7869), pp. 718-723. Date of Electronic Publication: 2021 Jun 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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Ningyan.Zhang@uth.tmc.edu.<br /><searchLink fieldCode="AU" term="%22Carroll+SF%22">Carroll SF</searchLink>; IGM Biosciences, Mountain View, CA, USA. scarroll@igmbio.com.<br /><searchLink fieldCode="AU" term="%22Shi+PY%22">Shi PY</searchLink>; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu.; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu.; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu.; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu.<br /><searchLink fieldCode="AU" term="%22An+Z%22">An Z</searchLink>; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA. 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