Senolytics reduce coronavirus-related mortality in old mice.
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| Title: | Senolytics reduce coronavirus-related mortality in old mice. |
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| Authors: | Camell CD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Yousefzadeh MJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Prata LGPL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Huggins MA; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA., Pierson M; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA., Zhang L; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., O'Kelly RD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Xun P; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA., Ejima K; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA., Xue A; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Tripathi U; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Espindola-Netto JM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Giorgadze N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Atkinson EJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Inman CL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Johnson KO; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Cholensky SH; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Carlson TW; Masonic Cancer Center Comparative Pathology Shared Resource, University of Minnesota, St. Paul, MN, USA.; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA., LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA., Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Division of Endocrinology, Department of Medicine, Mayo Clinic, Rochester, MN, USA., O'Sullivan MG; Masonic Cancer Center Comparative Pathology Shared Resource, University of Minnesota, St. Paul, MN, USA.; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA., Allison DB; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA., Jameson SC; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA., Meves A; Department of Dermatology, Mayo Clinic, Rochester, MN, USA., Li M; Department of Dermatology, Mayo Clinic, Rochester, MN, USA., Prakash YS; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA., Chiarella SE; Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Hamilton SE; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu., Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu., Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu. |
| Source: | Science (New York, N.Y.) [Science] 2021 Jul 16; Vol. 373 (6552). Date of Electronic Publication: 2021 Jun 08. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.abe4832 |
