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Senolytics reduce coronavirus-related mortality in old mice.

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Title: Senolytics reduce coronavirus-related mortality in old mice.
Authors: Camell CD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Yousefzadeh MJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Prata LGPL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Huggins MA; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA., Pierson M; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA., Zhang L; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., O'Kelly RD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Xun P; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA., Ejima K; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA., Xue A; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Tripathi U; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Espindola-Netto JM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Giorgadze N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Atkinson EJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Inman CL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Johnson KO; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Cholensky SH; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Carlson TW; Masonic Cancer Center Comparative Pathology Shared Resource, University of Minnesota, St. Paul, MN, USA.; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA., LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA., Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Division of Endocrinology, Department of Medicine, Mayo Clinic, Rochester, MN, USA., O'Sullivan MG; Masonic Cancer Center Comparative Pathology Shared Resource, University of Minnesota, St. Paul, MN, USA.; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA., Allison DB; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA., Jameson SC; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA., Meves A; Department of Dermatology, Mayo Clinic, Rochester, MN, USA., Li M; Department of Dermatology, Mayo Clinic, Rochester, MN, USA., Prakash YS; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA., Chiarella SE; Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Hamilton SE; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu., Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu., Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu.
Source: Science (New York, N.Y.) [Science] 2021 Jul 16; Vol. 373 (6552). Date of Electronic Publication: 2021 Jun 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Senolytics reduce coronavirus-related mortality in old mice.
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  Data: <searchLink fieldCode="AU" term="%22Camell+CD%22">Camell CD</searchLink>; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Yousefzadeh+MJ%22">Yousefzadeh MJ</searchLink>; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Prata+LGPL%22">Prata LGPL</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Huggins+MA%22">Huggins MA</searchLink>; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pierson+M%22">Pierson M</searchLink>; 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Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Division of Endocrinology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22O'Sullivan+MG%22">O'Sullivan MG</searchLink>; Masonic Cancer Center Comparative Pathology Shared Resource, University of Minnesota, St. Paul, MN, USA.; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA.<br /><searchLink fieldCode="AU" term="%22Allison+DB%22">Allison DB</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA.<br /><searchLink fieldCode="AU" term="%22Jameson+SC%22">Jameson SC</searchLink>; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Meves+A%22">Meves A</searchLink>; Department of Dermatology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Dermatology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Prakash+YS%22">Prakash YS</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Chiarella+SE%22">Chiarella SE</searchLink>; Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hamilton+SE%22">Hamilton SE</searchLink>; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu.<br /><searchLink fieldCode="AU" term="%22Tchkonia+T%22">Tchkonia T</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Niedernhofer+LJ%22">Niedernhofer LJ</searchLink>; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu.<br /><searchLink fieldCode="AU" term="%22Kirkland+JL%22">Kirkland JL</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+PD%22">Robbins PD</searchLink>; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. probbins@umn.edu kirkland.james@mayo.edu lniedern@umn.edu tchkonia.tamar@mayo.edu hamil062@umn.edu.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2021 Jul 16; Vol. 373 (6552). <i>Date of Electronic Publication: </i>2021 Jun 08.
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