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Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.

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Title: Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Authors: Leach JDG; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Vlahov N; Cancer Research UK Beatson Institute, Glasgow, UK., Tsantoulis P; Department of Medical Specialties, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Department of Oncology, Hôpitaux Universitaires de Genève, Geneva, Switzerland., Ridgway RA; Cancer Research UK Beatson Institute, Glasgow, UK., Flanagan DJ; Cancer Research UK Beatson Institute, Glasgow, UK., Gilroy K; Cancer Research UK Beatson Institute, Glasgow, UK., Sphyris N; Cancer Research UK Beatson Institute, Glasgow, UK., Vázquez EG; Gastrointestinal Stem Cell Biology Lab, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Vincent DF; Cancer Research UK Beatson Institute, Glasgow, UK., Faller WJ; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, The Netherlands., Hodder MC; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Raven A; Cancer Research UK Beatson Institute, Glasgow, UK., Fey S; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Najumudeen AK; Cancer Research UK Beatson Institute, Glasgow, UK., Strathdee D; Cancer Research UK Beatson Institute, Glasgow, UK., Nixon C; Cancer Research UK Beatson Institute, Glasgow, UK., Hughes M; Cancer Research UK Beatson Institute, Glasgow, UK., Clark W; Cancer Research UK Beatson Institute, Glasgow, UK., Shaw R; Cancer Research UK Beatson Institute, Glasgow, UK., van Hooff SR; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.; Oncode Institute, Academic Medical Center, Amsterdam, The Netherlands., Huels DJ; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.; Oncode Institute, Academic Medical Center, Amsterdam, The Netherlands., Medema JP; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.; Oncode Institute, Academic Medical Center, Amsterdam, The Netherlands., Barry ST; Bioscience, Early Oncology, AstraZeneca, Cambridge, UK., Frame MC; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Unciti-Broceta A; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Leedham SJ; Gastrointestinal Stem Cell Biology Lab, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Inman GJ; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Jackstadt R; Cancer Research UK Beatson Institute, Glasgow, UK., Thompson BJ; EMBL Australia, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Campbell AD; Cancer Research UK Beatson Institute, Glasgow, UK., Tejpar S; Molecular Digestive Oncology, Department of Oncology, University of Leuven, Leuven, Belgium., Sansom OJ; Cancer Research UK Beatson Institute, Glasgow, UK. o.sansom@beatson.gla.ac.uk.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. o.sansom@beatson.gla.ac.uk.
Corporate Authors: S:CORT consortium
Source: Nature communications [Nat Commun] 2021 Jun 08; Vol. 12 (1), pp. 3464. Date of Electronic Publication: 2021 Jun 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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Cancer Research UK Beatson Institute, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Vázquez+EG%22">Vázquez EG</searchLink>; Gastrointestinal Stem Cell Biology Lab, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Vincent+DF%22">Vincent DF</searchLink>; Cancer Research UK Beatson Institute, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Faller+WJ%22">Faller WJ</searchLink>; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hodder+MC%22">Hodder MC</searchLink>; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Raven+A%22">Raven A</searchLink>; Cancer Research UK Beatson Institute, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Fey+S%22">Fey S</searchLink>; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Najumudeen+AK%22">Najumudeen AK</searchLink>; 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