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Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.

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Title: Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
Authors: Freeman-Cook KD; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Hoffman RL; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Behenna DC; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Boras B; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Carelli J; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Diehl W; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Ferre RA; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., He YA; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Hui A; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Huang B; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Huser N; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Jones R; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Kephart SE; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Lapek J; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., McTigue M; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Miller N; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Murray BW; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Nagata A; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Nguyen L; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Niessen S; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Ninkovic S; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., O'Doherty I; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Ornelas MA; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Solowiej J; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Sutton SC; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Tran K; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Tseng E; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Visswanathan R; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Xu M; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Zehnder L; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Zhang Q; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Zhang C; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States., Dann S; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 9056-9077. Date of Electronic Publication: 2021 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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IllustrationInfo
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  Data: Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Freeman-Cook+KD%22">Freeman-Cook KD</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Hoffman+RL%22">Hoffman RL</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Behenna+DC%22">Behenna DC</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Boras+B%22">Boras B</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Carelli+J%22">Carelli J</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Diehl+W%22">Diehl W</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Ferre+RA%22">Ferre RA</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22He+YA%22">He YA</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Hui+A%22">Hui A</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Huang+B%22">Huang B</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Huser+N%22">Huser N</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Jones+R%22">Jones R</searchLink>; 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Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Nguyen+L%22">Nguyen L</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Niessen+S%22">Niessen S</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Ninkovic+S%22">Ninkovic S</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22O'Doherty+I%22">O'Doherty I</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Ornelas+MA%22">Ornelas MA</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Solowiej+J%22">Solowiej J</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Sutton+SC%22">Sutton SC</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Tran+K%22">Tran K</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Tseng+E%22">Tseng E</searchLink>; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Visswanathan+R%22">Visswanathan R</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Zehnder+L%22">Zehnder L</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Dann+S%22">Dann S</searchLink>; Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, California 92121, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 9056-9077. <i>Date of Electronic Publication: </i>2021 Jun 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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