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Phenyl bioisosteres in medicinal chemistry: discovery of novel γ-secretase modulators as a potential treatment for Alzheimer's disease.

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Title: Phenyl bioisosteres in medicinal chemistry: discovery of novel γ-secretase modulators as a potential treatment for Alzheimer's disease.
Authors: Ratni H; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Baumann K; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Bellotti P; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Cook XA; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Green LG; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Luebbers T; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Reutlinger M; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Stepan AF; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Vifian W; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.
Source: RSC medicinal chemistry [RSC Med Chem] 2021 Apr 12; Vol. 12 (5), pp. 758-766. Date of Electronic Publication: 2021 Apr 12 (Print Publication: 2021).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Phenyl bioisosteres in medicinal chemistry: discovery of novel γ-secretase modulators as a potential treatment for Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Ratni+H%22">Ratni H</searchLink>; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.<br /><searchLink fieldCode="AU" term="%22Baumann+K%22">Baumann K</searchLink>; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.<br /><searchLink fieldCode="AU" term="%22Bellotti+P%22">Bellotti P</searchLink>; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.<br /><searchLink fieldCode="AU" term="%22Cook+XA%22">Cook XA</searchLink>; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.<br /><searchLink fieldCode="AU" term="%22Green+LG%22">Green LG</searchLink>; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.<br /><searchLink fieldCode="AU" term="%22Luebbers+T%22">Luebbers T</searchLink>; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.<br /><searchLink fieldCode="AU" term="%22Reutlinger+M%22">Reutlinger M</searchLink>; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.<br /><searchLink fieldCode="AU" term="%22Stepan+AF%22">Stepan AF</searchLink>; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.<br /><searchLink fieldCode="AU" term="%22Vifian+W%22">Vifian W</searchLink>; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.
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  Data: <searchLink fieldCode="JN" term="%22101759460%22">RSC medicinal chemistry</searchLink> [RSC Med Chem] 2021 Apr 12; Vol. 12 (5), pp. 758-766. <i>Date of Electronic Publication: </i>2021 Apr 12 (<i>Print Publication: </i>2021).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101759460 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2632-8682 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226328682%22">26328682 </searchLink><i>NLM ISO Abbreviation: </i>RSC Med Chem <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1039/d1md00043h
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              Text: 2021 Apr 12
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