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The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.

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Title: The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.
Authors: Copin R; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Baum A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Wloga E; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Pascal KE; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Giordano S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Fulton BO; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Zhou A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Negron N; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Lanza K; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Chan N; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Coppola A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Chiu J; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Ni M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Wei Y; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Atwal GS; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Hernandez AR; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Saotome K; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Zhou Y; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Franklin MC; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Hooper AT; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., McCarthy S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Hamon S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Hamilton JD; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Staples HM; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA., Alfson K; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA., Carrion R Jr; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA., Ali S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Norton T; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Somersan-Karakaya S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Sivapalasingam S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Herman GA; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Weinreich DM; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Lipsich L; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Stahl N; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Murphy AJ; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Yancopoulos GD; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Kyratsous CA; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: christos.kyratsous@regeneron.com.
Source: Cell [Cell] 2021 Jul 22; Vol. 184 (15), pp. 3949-3961.e11. Date of Electronic Publication: 2021 Jun 05.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.
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  Data: <searchLink fieldCode="AU" term="%22Copin+R%22">Copin R</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Baum+A%22">Baum A</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Wloga+E%22">Wloga E</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Pascal+KE%22">Pascal KE</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Giordano+S%22">Giordano S</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Fulton+BO%22">Fulton BO</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+A%22">Zhou A</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Negron+N%22">Negron N</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Lanza+K%22">Lanza K</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Chan+N%22">Chan N</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Coppola+A%22">Coppola A</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Chiu+J%22">Chiu J</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Ni+M%22">Ni M</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Wei+Y%22">Wei Y</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Atwal+GS%22">Atwal GS</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez+AR%22">Hernandez AR</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Saotome+K%22">Saotome K</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Franklin+MC%22">Franklin MC</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Hooper+AT%22">Hooper AT</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22McCarthy+S%22">McCarthy S</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Hamon+S%22">Hamon S</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Hamilton+JD%22">Hamilton JD</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Staples+HM%22">Staples HM</searchLink>; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.<br /><searchLink fieldCode="AU" term="%22Alfson+K%22">Alfson K</searchLink>; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.<br /><searchLink fieldCode="AU" term="%22Carrion+R+Jr%22">Carrion R Jr</searchLink>; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.<br /><searchLink fieldCode="AU" term="%22Ali+S%22">Ali S</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Norton+T%22">Norton T</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Somersan-Karakaya+S%22">Somersan-Karakaya S</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Sivapalasingam+S%22">Sivapalasingam S</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Herman+GA%22">Herman GA</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Weinreich+DM%22">Weinreich DM</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Lipsich+L%22">Lipsich L</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Stahl+N%22">Stahl N</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+AJ%22">Murphy AJ</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Yancopoulos+GD%22">Yancopoulos GD</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Kyratsous+CA%22">Kyratsous CA</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. Electronic address: christos.kyratsous@regeneron.com.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2021 Jul 22; Vol. 184 (15), pp. 3949-3961.e11. <i>Date of Electronic Publication: </i>2021 Jun 05.
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  Data: Clinical Trial, Phase I; Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.
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