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Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System.

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Title: Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System.
Authors: Sharrock AV; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.; Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand., McManaway SP; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Rich MH; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand., Mumm JS; The Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States., Hermans IF; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.; Malaghan Institute of Medical Research, Wellington, New Zealand., Tercel M; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Pruijn FB; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Ackerley DF; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.; Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.
Source: Frontiers in pharmacology [Front Pharmacol] 2021 Jun 07; Vol. 12, pp. 701456. Date of Electronic Publication: 2021 Jun 07 (Print Publication: 2021).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
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