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A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage.

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Title: A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage.
Authors: Zou X; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Koh GCC; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Nanda AS; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Degasperi A; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Urgo K; Wellcome Sanger Institute, Hinxton, UK., Roumeliotis TI; The Institute of Cancer Research, Chester Beatty Laboratories, London, UK., Agu CA; Wellcome Sanger Institute, Hinxton, UK., Badja C; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Momen S; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Young J; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Amarante TD; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Side L; UCL Institute for Women's Health, Great Ormond Street Hospital, London, UK.; Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK., Brice G; Southwest Thames Regional Genetics Service, St George's University of London, London, UK., Perez-Alonso V; Pediatrics Department, Doce de Octubre University Hospital, i+12 Research Institute, Madrid, Spain., Rueda D; Hereditary Cancer Laboratory, Doce de Octubre University Hospital, i+12 Research Institute, Madrid, Spain., Gomez C; Wellcome Sanger Institute, Hinxton, UK., Bushell W; Wellcome Sanger Institute, Hinxton, UK., Harris R; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Choudhary JS; The Institute of Cancer Research, Chester Beatty Laboratories, London, UK., Jiricny J; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.; Institute of Biochemistry, ETH Zurich, Zurich, Switzerland., Skarnes WC; Wellcome Sanger Institute, Hinxton, UK.; William Harvey Research Institute, Queen Mary University of London, London, UK., Nik-Zainal S; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK. snz@mrc-cu.cam.ac.uk.; MRC Cancer Unit, University of Cambridge, Cambridge, UK. snz@mrc-cu.cam.ac.uk.; Wellcome Sanger Institute, Hinxton, UK. snz@mrc-cu.cam.ac.uk.
Corporate Authors: Genomics England Research Consortium
Source: Nature cancer [Nat Cancer] 2021 Jun; Vol. 2 (6), pp. 643-657. Date of Electronic Publication: 2021 Apr 26.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zou+X%22">Zou X</searchLink>; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Koh+GCC%22">Koh GCC</searchLink>; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Nanda+AS%22">Nanda AS</searchLink>; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Degasperi+A%22">Degasperi A</searchLink>; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Urgo+K%22">Urgo K</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Roumeliotis+TI%22">Roumeliotis TI</searchLink>; The Institute of Cancer Research, Chester Beatty Laboratories, London, UK.<br /><searchLink fieldCode="AU" term="%22Agu+CA%22">Agu CA</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Badja+C%22">Badja C</searchLink>; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Momen+S%22">Momen S</searchLink>; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Young+J%22">Young J</searchLink>; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Amarante+TD%22">Amarante TD</searchLink>; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Side+L%22">Side L</searchLink>; UCL Institute for Women's Health, Great Ormond Street Hospital, London, UK.; Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Brice+G%22">Brice G</searchLink>; Southwest Thames Regional Genetics Service, St George's University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Perez-Alonso+V%22">Perez-Alonso V</searchLink>; Pediatrics Department, Doce de Octubre University Hospital, i+12 Research Institute, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rueda+D%22">Rueda D</searchLink>; Hereditary Cancer Laboratory, Doce de Octubre University Hospital, i+12 Research Institute, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gomez+C%22">Gomez C</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Bushell+W%22">Bushell W</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Harris+R%22">Harris R</searchLink>; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Choudhary+JS%22">Choudhary JS</searchLink>; The Institute of Cancer Research, Chester Beatty Laboratories, London, UK.<br /><searchLink fieldCode="AU" term="%22Jiricny+J%22">Jiricny J</searchLink>; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.; Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Skarnes+WC%22">Skarnes WC</searchLink>; Wellcome Sanger Institute, Hinxton, UK.; William Harvey Research Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Nik-Zainal+S%22">Nik-Zainal S</searchLink>; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK. snz@mrc-cu.cam.ac.uk.; MRC Cancer Unit, University of Cambridge, Cambridge, UK. snz@mrc-cu.cam.ac.uk.; Wellcome Sanger Institute, Hinxton, UK. snz@mrc-cu.cam.ac.uk.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101761119 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-1347 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226621347%22">26621347 </searchLink><i>NLM ISO Abbreviation: </i>Nat Cancer
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        Value: 10.1038/s43018-021-00200-0
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