Safety and Pharmacokinetics of HTL0018318, a Novel M1 Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects.
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| Title: | Safety and Pharmacokinetics of HTL0018318, a Novel M |
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| Authors: | Bakker C; Centre for Human Drug Research (CDHR), Leiden, The Netherlands. cbakker@chdr.nl.; Leids Universitair Medisch Centrum, Leiden, The Netherlands. cbakker@chdr.nl., van der Aart J; Centre for Human Drug Research (CDHR), Leiden, The Netherlands., Labots G; Centre for Human Drug Research (CDHR), Leiden, The Netherlands., Liptrot J; Sosei Heptares, Cambridge, UK., Cross DM; Cross Pharma Consulting Ltd, Cambridge, UK., Klaassen ES; Centre for Human Drug Research (CDHR), Leiden, The Netherlands., Dickinson S; Sosei Heptares, Cambridge, UK., Tasker T; Sosei Heptares, Cambridge, UK., Groeneveld GJ; Centre for Human Drug Research (CDHR), Leiden, The Netherlands.; Leids Universitair Medisch Centrum, Leiden, The Netherlands. |
| Source: | Drugs in R&D [Drugs R D] 2021 Sep; Vol. 21 (3), pp. 295-304. Date of Electronic Publication: 2021 Jun 23. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 100883647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-6901 (Electronic) Linking ISSN: 11745886 NLM ISO Abbreviation: Drugs R D Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 34164794 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Safety and Pharmacokinetics of HTL0018318, a Novel M<subscript>1</subscript> Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bakker+C%22">Bakker C</searchLink>; Centre for Human Drug Research (CDHR), Leiden, The Netherlands. cbakker@chdr.nl.; Leids Universitair Medisch Centrum, Leiden, The Netherlands. cbakker@chdr.nl.<br /><searchLink fieldCode="AU" term="%22van+der+Aart+J%22">van der Aart J</searchLink>; Centre for Human Drug Research (CDHR), Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Labots+G%22">Labots G</searchLink>; Centre for Human Drug Research (CDHR), Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Liptrot+J%22">Liptrot J</searchLink>; Sosei Heptares, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cross+DM%22">Cross DM</searchLink>; Cross Pharma Consulting Ltd, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Klaassen+ES%22">Klaassen ES</searchLink>; Centre for Human Drug Research (CDHR), Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Dickinson+S%22">Dickinson S</searchLink>; Sosei Heptares, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tasker+T%22">Tasker T</searchLink>; Sosei Heptares, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Groeneveld+GJ%22">Groeneveld GJ</searchLink>; Centre for Human Drug Research (CDHR), Leiden, The Netherlands.; Leids Universitair Medisch Centrum, Leiden, The Netherlands. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100883647%22">Drugs in R&D</searchLink> [Drugs R D] 2021 Sep; Vol. 21 (3), pp. 295-304. <i>Date of Electronic Publication: </i>2021 Jun 23. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Adis%2C+Springer+International%22">Adis, Springer International </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>100883647 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1179-6901 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211745886%22">11745886 </searchLink><i>NLM ISO Abbreviation: </i>Drugs R D <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=34164794 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s40268-021-00352-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 295 Titles: – TitleFull: Safety and Pharmacokinetics of HTL0018318, a Novel M1 Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bakker C – PersonEntity: Name: NameFull: van der Aart J – PersonEntity: Name: NameFull: Labots G – PersonEntity: Name: NameFull: Liptrot J – PersonEntity: Name: NameFull: Cross DM – PersonEntity: Name: NameFull: Klaassen ES – PersonEntity: Name: NameFull: Dickinson S – PersonEntity: Name: NameFull: Tasker T – PersonEntity: Name: NameFull: Groeneveld GJ IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: 2021 Sep Type: published Y: 2021 Identifiers: – Type: issn-electronic Value: 1179-6901 Numbering: – Type: volume Value: 21 – Type: issue Value: 3 Titles: – TitleFull: Drugs in R&D Type: main |
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