Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.

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Title: Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.
Authors: Meng B; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK., Kemp SA; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; Division of Infection and Immunity, University College London, London, UK., Papa G; MRC - Laboratory of Molecular Biology, Cambridge, UK., Datir R; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK., Ferreira IATM; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK., Marelli S; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK., Harvey WT; Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK; MRC - University of Glasgow Centre for Virus Research, Glasgow, UK., Lytras S; MRC - University of Glasgow Centre for Virus Research, Glasgow, UK., Mohamed A; Pirbright Institute, Woking, Surrey, UK., Gallo G; Pirbright Institute, Woking, Surrey, UK., Thakur N; Pirbright Institute, Woking, Surrey, UK., Collier DA; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; Division of Infection and Immunity, University College London, London, UK., Mlcochova P; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK., Duncan LM; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK., Carabelli AM; Department of Medicine, University of Cambridge, Cambridge, UK., Kenyon JC; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lever AM; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., De Marco A; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Saliba C; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Culap K; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Cameroni E; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Matheson NJ; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; NHS Blood and Transplant, Cambridge, UK., Piccoli L; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Corti D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., James LC; MRC - Laboratory of Molecular Biology, Cambridge, UK., Robertson DL; MRC - University of Glasgow Centre for Virus Research, Glasgow, UK., Bailey D; Pirbright Institute, Woking, Surrey, UK. Electronic address: dalan.bailey@pirbright.ac.uk., Gupta RK; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; Africa Health Research Institute, Durban, South Africa. Electronic address: rkg20@cam.ac.uk.
Corporate Authors: COVID-19 Genomics UK (COG-UK) Consortium; https://www.cogconsortium.uk.
Source: Cell reports [Cell Rep] 2021 Jun 29; Vol. 35 (13), pp. 109292. Date of Electronic Publication: 2021 Jun 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.
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  Data: <searchLink fieldCode="AU" term="%22Meng+B%22">Meng B</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kemp+SA%22">Kemp SA</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; Division of Infection and Immunity, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Papa+G%22">Papa G</searchLink>; MRC - Laboratory of Molecular Biology, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Datir+R%22">Datir R</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ferreira+IATM%22">Ferreira IATM</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Marelli+S%22">Marelli S</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Harvey+WT%22">Harvey WT</searchLink>; Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK; MRC - University of Glasgow Centre for Virus Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Lytras+S%22">Lytras S</searchLink>; MRC - University of Glasgow Centre for Virus Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Mohamed+A%22">Mohamed A</searchLink>; Pirbright Institute, Woking, Surrey, UK.<br /><searchLink fieldCode="AU" term="%22Gallo+G%22">Gallo G</searchLink>; Pirbright Institute, Woking, Surrey, UK.<br /><searchLink fieldCode="AU" term="%22Thakur+N%22">Thakur N</searchLink>; Pirbright Institute, Woking, Surrey, UK.<br /><searchLink fieldCode="AU" term="%22Collier+DA%22">Collier DA</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; Division of Infection and Immunity, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mlcochova+P%22">Mlcochova P</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Duncan+LM%22">Duncan LM</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Carabelli+AM%22">Carabelli AM</searchLink>; Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kenyon+JC%22">Kenyon JC</searchLink>; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lever+AM%22">Lever AM</searchLink>; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22De+Marco+A%22">De Marco A</searchLink>; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Saliba+C%22">Saliba C</searchLink>; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Culap+K%22">Culap K</searchLink>; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cameroni+E%22">Cameroni E</searchLink>; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Matheson+NJ%22">Matheson NJ</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; NHS Blood and Transplant, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Piccoli+L%22">Piccoli L</searchLink>; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Corti+D%22">Corti D</searchLink>; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22James+LC%22">James LC</searchLink>; MRC - Laboratory of Molecular Biology, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Robertson+DL%22">Robertson DL</searchLink>; MRC - University of Glasgow Centre for Virus Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Bailey+D%22">Bailey D</searchLink>; Pirbright Institute, Woking, Surrey, UK. Electronic address: dalan.bailey@pirbright.ac.uk.<br /><searchLink fieldCode="AU" term="%22Gupta+RK%22">Gupta RK</searchLink>; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; Africa Health Research Institute, Durban, South Africa. Electronic address: rkg20@cam.ac.uk.
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  Data: <searchLink fieldCode="CA" term="%22COVID-19+Genomics+UK+%28COG-UK%29+Consortium%22">COVID-19 Genomics UK (COG-UK) Consortium</searchLink>; https://www.cogconsortium.uk.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2021 Jun 29; Vol. 35 (13), pp. 109292. <i>Date of Electronic Publication: </i>2021 Jun 08.
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