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Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa.

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Title: Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa.
Authors: Zhang L; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Chen C; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Fu J; The Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Lilley B; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Berlinicke C; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Hansen B; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Ding D; Department of Biostatistics, Johns Hopkins University, Baltimore, United States., Wang G; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Wang T; The Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States.; School of Chemistry, Xuzhou College of Industrial Technology, Xuzhou, China.; College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing, China., Shou D; The Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Ye Y; The Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Mulligan T; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Emmerich K; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States.; Department of Genetic Medicine, Johns Hopkins University, Baltimore, United States., Saxena MT; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Hall KR; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand., Sharrock AV; Department of Biostatistics, Johns Hopkins University, Baltimore, United States.; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand., Brandon C; Department of Ophthalmology, Medical University of South Carolina, Charleston, United States., Park H; Department of Neurology, Johns Hopkins University, Baltimore, United States., Kam TI; Department of Neurology, Johns Hopkins University, Baltimore, United States.; Institute for Cell Engineering, Johns Hopkins University, Baltimore, United States., Dawson VL; Department of Neurology, Johns Hopkins University, Baltimore, United States.; Institute for Cell Engineering, Johns Hopkins University, Baltimore, United States.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, United States.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States., Dawson TM; Department of Neurology, Johns Hopkins University, Baltimore, United States.; Institute for Cell Engineering, Johns Hopkins University, Baltimore, United States.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, United States.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States., Shim JS; Faculty of Health Sciences, University of Macau, Taipa, Macau, China., Hanes J; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States.; The Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Ji H; Department of Biostatistics, Johns Hopkins University, Baltimore, United States., Liu JO; Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, United States.; Department of Oncology, Johns Hopkins University, Baltimore, United States., Qian J; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States., Ackerley DF; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand., Rohrer B; Department of Ophthalmology, Medical University of South Carolina, Charleston, United States., Zack DJ; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States.; The Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States.; Department of Genetic Medicine, Johns Hopkins University, Baltimore, United States.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States.; Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, United States., Mumm JS; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States.; The Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States.; Department of Genetic Medicine, Johns Hopkins University, Baltimore, United States.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States.
Source: ELife [Elife] 2021 Jun 29; Vol. 10. Date of Electronic Publication: 2021 Jun 29.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa.
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Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States.<br /><searchLink fieldCode="AU" term="%22Dawson+TM%22">Dawson TM</searchLink>; Department of Neurology, Johns Hopkins University, Baltimore, United States.; Institute for Cell Engineering, Johns Hopkins University, Baltimore, United States.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, United States.; Solomon H. 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