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Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: Initial Results From the Pembrolizumab Arm of a Phase 2 Randomized Clinical Trial.

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Title: Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: Initial Results From the Pembrolizumab Arm of a Phase 2 Randomized Clinical Trial.
Authors: Rahma OE; NRG Oncology, Philadelphia, Pennsylvania.; Department of Medical Oncology, Dana-Farber Cancer Institute/Alliance, Boston, Massachusetts., Yothers G; NRG Oncology, Philadelphia, Pennsylvania.; Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania., Hong TS; NRG Oncology, Philadelphia, Pennsylvania.; Department of Radiation Oncology, Massachusetts General Hospital, Boston., Russell MM; NRG Oncology, Philadelphia, Pennsylvania.; Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California.; David Geffen School of Medicine at UCLA, Los Angeles, California., You YN; Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston., Parker W; NRG Oncology, Philadelphia, Pennsylvania.; Department of Medical Physics, McGill University Health Centre, Montréal, Quebec, Canada., Jacobs SA; NRG Oncology, Philadelphia, Pennsylvania., Colangelo LH; NRG Oncology, Philadelphia, Pennsylvania.; Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania., Lucas PC; NRG Oncology, Philadelphia, Pennsylvania.; Department of Pathology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Gollub MJ; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York., Hall WA; NRG Oncology, Philadelphia, Pennsylvania.; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee., Kachnic LA; NRG Oncology, Philadelphia, Pennsylvania.; Department of Radiation Oncology, Columbia University Irving Medical Center, Herbert Irving Comprehensive Cancer Center, New York, New York.; SWOG Cancer Research Network, San Antonio, Texas., Vijayvergia N; NRG Oncology, Philadelphia, Pennsylvania.; Fox Chase Cancer Center, Philadelphia, Pennsylvania., O'Rourke MA; NRG Oncology, Philadelphia, Pennsylvania.; National Cancer Institute Community Oncology Research Program, Prisma Health Cancer Institute, Greenville, South Carolina., Faller BA; Missouri Baptist Medical Center, Heartland Cancer Research, National Cancer Institute Community Oncology Research Program, St Louis., Valicenti RK; Department of Radiation Oncology, UC Davis, Davis, California., Schefter TE; NRG Oncology, Philadelphia, Pennsylvania.; Department of Radiation Oncology, University of Colorado Cancer Center, Aurora., George S; Section of Hematology/Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City., Kainthla R; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas., Stella PJ; NRG Oncology, Philadelphia, Pennsylvania.; Department of Medical Oncology, St Joseph Mercy Hospital, Ann Arbor, Michigan., Sigurdson E; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Wolmark N; NRG Oncology, Philadelphia, Pennsylvania.; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania., George TJ; NRG Oncology, Philadelphia, Pennsylvania.; Department of Medicine, University of Florida Health Cancer Center, Gainesville.
Source: JAMA oncology [JAMA Oncol] 2021 Aug 01; Vol. 7 (8), pp. 1225-1230.
Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101652861 Publication Model: Print Cited Medium: Internet ISSN: 2374-2445 (Electronic) Linking ISSN: 23742437 NLM ISO Abbreviation: JAMA Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: Initial Results From the Pembrolizumab Arm of a Phase 2 Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Rahma+OE%22">Rahma OE</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Medical Oncology, Dana-Farber Cancer Institute/Alliance, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Yothers+G%22">Yothers G</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Hong+TS%22">Hong TS</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Radiation Oncology, Massachusetts General Hospital, Boston.<br /><searchLink fieldCode="AU" term="%22Russell+MM%22">Russell MM</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California.; David Geffen School of Medicine at UCLA, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22You+YN%22">You YN</searchLink>; Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston.<br /><searchLink fieldCode="AU" term="%22Parker+W%22">Parker W</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Medical Physics, McGill University Health Centre, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Jacobs+SA%22">Jacobs SA</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Colangelo+LH%22">Colangelo LH</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Lucas+PC%22">Lucas PC</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Pathology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Gollub+MJ%22">Gollub MJ</searchLink>; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Hall+WA%22">Hall WA</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee.<br /><searchLink fieldCode="AU" term="%22Kachnic+LA%22">Kachnic LA</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Radiation Oncology, Columbia University Irving Medical Center, Herbert Irving Comprehensive Cancer Center, New York, New York.; SWOG Cancer Research Network, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Vijayvergia+N%22">Vijayvergia N</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22O'Rourke+MA%22">O'Rourke MA</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; National Cancer Institute Community Oncology Research Program, Prisma Health Cancer Institute, Greenville, South Carolina.<br /><searchLink fieldCode="AU" term="%22Faller+BA%22">Faller BA</searchLink>; Missouri Baptist Medical Center, Heartland Cancer Research, National Cancer Institute Community Oncology Research Program, St Louis.<br /><searchLink fieldCode="AU" term="%22Valicenti+RK%22">Valicenti RK</searchLink>; Department of Radiation Oncology, UC Davis, Davis, California.<br /><searchLink fieldCode="AU" term="%22Schefter+TE%22">Schefter TE</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Radiation Oncology, University of Colorado Cancer Center, Aurora.<br /><searchLink fieldCode="AU" term="%22George+S%22">George S</searchLink>; Section of Hematology/Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City.<br /><searchLink fieldCode="AU" term="%22Kainthla+R%22">Kainthla R</searchLink>; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas.<br /><searchLink fieldCode="AU" term="%22Stella+PJ%22">Stella PJ</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Medical Oncology, St Joseph Mercy Hospital, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Sigurdson+E%22">Sigurdson E</searchLink>; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Wolmark+N%22">Wolmark N</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22George+TJ%22">George TJ</searchLink>; NRG Oncology, Philadelphia, Pennsylvania.; Department of Medicine, University of Florida Health Cancer Center, Gainesville.
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  Data: <searchLink fieldCode="JN" term="%22101652861%22">JAMA oncology</searchLink> [JAMA Oncol] 2021 Aug 01; Vol. 7 (8), pp. 1225-1230.
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  Data: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101652861 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2374-2445 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223742437%22">23742437 </searchLink><i>NLM ISO Abbreviation: </i>JAMA Oncol <i>Subsets: </i>MEDLINE
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        Value: 10.1001/jamaoncol.2021.1683
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