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Impaired respiratory burst contributes to infections in PKCδ-deficient patients.

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Title: Impaired respiratory burst contributes to infections in PKCδ-deficient patients.
Authors: Neehus AL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; Institute of Experimental Hematology, REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany., Moriya K; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France., Nieto-Patlán A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; Research and Development in Bioprocess Unit, National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico.; National Laboratory for Specialized Services of Investigation, Development and Innovation for Pharma Chemicals and Biotechnological Products, LANSEIDI-FarBiotec-CONACyT, Mexico City, Mexico., Le Voyer T; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France., Lévy R; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, Paris, France., Özen A; Department of Pediatrics, Division of Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey., Karakoc-Aydiner E; Department of Pediatrics, Division of Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey., Baris S; Department of Pediatrics, Division of Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey., Yildiran A; Department of Pediatric Immunology and Allergy, Ondokuz Mayıs University School of Medicine, Samsun, Turkey., Altundag E; Department of Medical Genetics, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey., Roynard M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France., Haake K; Institute of Experimental Hematology, REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany., Migaud M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France., Dorgham K; Sorbonne University, Institut National de la Santé et de la Recherche Médicale, Center for Immunology and Microbial Infections, CIMI-Paris, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Immunology, Paris, France., Gorochov G; Sorbonne University, Institut National de la Santé et de la Recherche Médicale, Center for Immunology and Microbial Infections, CIMI-Paris, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Immunology, Paris, France., Abel L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY., Lachmann N; Institute of Experimental Hematology, REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany., Dogu F; Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey., Haskologlu S; Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey., İnce E; Department of Pediatric Infectious Disease, Ankara University School of Medicine, Ankara, Turkey., El-Benna J; University of Paris, Institut National de la Santé et de la Recherche Médical U1149, Centre National de la Recherche Scientifique-ERL8252, Paris, France.; Center for Research on Inflammation, Laboratory of Excellence Inflamex, Faculty of Medicine, Xavier Bichat, Paris, France., Uzel G; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Kiykim A; Pediatric Allergy and Immunology, Marmara University Pediatric Training and Research Hospital, Istanbul, Turkey.; Division of Pediatric Allergy and Immunology, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey., Boztug K; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; St. Anna Children's Cancer Research Institute, Vienna, Austria., Roderick MR; Pediatric Immunology and Infectious Disease, Bristol Royal Hospital for Children, Bristol, UK., Shahrooei M; Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran.; Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, Katholieke Universiteit Leuven, Leuven, Belgium., Brogan PA; Infection, Inflammation, and Rheumatology Section, Infection, Immunity, Inflammation and Physiological Medicine Programme, University College London Institute of Child Health, London, UK., Abolhassani H; Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden.; Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran., Hancioglu G; Department of Pediatric Immunology and Allergy, Ondokuz Mayıs University School of Medicine, Samsun, Turkey., Parvaneh N; Department of Pediatrics, Division of Allergy and Clinical Immunology, Tehran University of Medical Sciences, Tehran, Iran.; Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran., Belot A; Reference Center for Rare Rheumatic and Autoimmune Diseases in Children, Pediatric Rheumatology, Hospices Civils de Lyon, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, UMS3444/US8 Lyon University, Lyon, France., Ikinciogullari A; Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey., Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.; Howard Hughes Medical Institute, New York, NY., Puel A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY., Bustamante J; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.; Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris, Paris, France.
Source: The Journal of experimental medicine [J Exp Med] 2021 Sep 06; Vol. 218 (9). Date of Electronic Publication: 2021 Jul 15.
Publication Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
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  Data: Impaired respiratory burst contributes to infections in PKCδ-deficient patients.
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  Data: <searchLink fieldCode="AU" term="%22Neehus+AL%22">Neehus AL</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; Institute of Experimental Hematology, REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Moriya+K%22">Moriya K</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Nieto-Patlán+A%22">Nieto-Patlán A</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; Research and Development in Bioprocess Unit, National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico.; National Laboratory for Specialized Services of Investigation, Development and Innovation for Pharma Chemicals and Biotechnological Products, LANSEIDI-FarBiotec-CONACyT, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Le+Voyer+T%22">Le Voyer T</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Lévy+R%22">Lévy R</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, Paris, France.<br /><searchLink fieldCode="AU" term="%22Özen+A%22">Özen A</searchLink>; Department of Pediatrics, Division of Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Karakoc-Aydiner+E%22">Karakoc-Aydiner E</searchLink>; Department of Pediatrics, Division of Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Baris+S%22">Baris S</searchLink>; Department of Pediatrics, Division of Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Yildiran+A%22">Yildiran A</searchLink>; Department of Pediatric Immunology and Allergy, Ondokuz Mayıs University School of Medicine, Samsun, Turkey.<br /><searchLink fieldCode="AU" term="%22Altundag+E%22">Altundag E</searchLink>; Department of Medical Genetics, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.<br /><searchLink fieldCode="AU" term="%22Roynard+M%22">Roynard M</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Haake+K%22">Haake K</searchLink>; Institute of Experimental Hematology, REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Migaud+M%22">Migaud M</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dorgham+K%22">Dorgham K</searchLink>; Sorbonne University, Institut National de la Santé et de la Recherche Médicale, Center for Immunology and Microbial Infections, CIMI-Paris, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Immunology, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gorochov+G%22">Gorochov G</searchLink>; Sorbonne University, Institut National de la Santé et de la Recherche Médicale, Center for Immunology and Microbial Infections, CIMI-Paris, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Immunology, Paris, France.<br /><searchLink fieldCode="AU" term="%22Abel+L%22">Abel L</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.<br /><searchLink fieldCode="AU" term="%22Lachmann+N%22">Lachmann N</searchLink>; Institute of Experimental Hematology, REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Dogu+F%22">Dogu F</searchLink>; Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Haskologlu+S%22">Haskologlu S</searchLink>; Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22İnce+E%22">İnce E</searchLink>; Department of Pediatric Infectious Disease, Ankara University School of Medicine, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22El-Benna+J%22">El-Benna J</searchLink>; University of Paris, Institut National de la Santé et de la Recherche Médical U1149, Centre National de la Recherche Scientifique-ERL8252, Paris, France.; Center for Research on Inflammation, Laboratory of Excellence Inflamex, Faculty of Medicine, Xavier Bichat, Paris, France.<br /><searchLink fieldCode="AU" term="%22Uzel+G%22">Uzel G</searchLink>; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Kiykim+A%22">Kiykim A</searchLink>; Pediatric Allergy and Immunology, Marmara University Pediatric Training and Research Hospital, Istanbul, Turkey.; Division of Pediatric Allergy and Immunology, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Boztug+K%22">Boztug K</searchLink>; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; St. Anna Children's Cancer Research Institute, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Roderick+MR%22">Roderick MR</searchLink>; Pediatric Immunology and Infectious Disease, Bristol Royal Hospital for Children, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Shahrooei+M%22">Shahrooei M</searchLink>; Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran.; Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, Katholieke Universiteit Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Brogan+PA%22">Brogan PA</searchLink>; Infection, Inflammation, and Rheumatology Section, Infection, Immunity, Inflammation and Physiological Medicine Programme, University College London Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Abolhassani+H%22">Abolhassani H</searchLink>; Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden.; Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Hancioglu+G%22">Hancioglu G</searchLink>; Department of Pediatric Immunology and Allergy, Ondokuz Mayıs University School of Medicine, Samsun, Turkey.<br /><searchLink fieldCode="AU" term="%22Parvaneh+N%22">Parvaneh N</searchLink>; Department of Pediatrics, Division of Allergy and Clinical Immunology, Tehran University of Medical Sciences, Tehran, Iran.; Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Belot+A%22">Belot A</searchLink>; Reference Center for Rare Rheumatic and Autoimmune Diseases in Children, Pediatric Rheumatology, Hospices Civils de Lyon, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, UMS3444/US8 Lyon University, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Ikinciogullari+A%22">Ikinciogullari A</searchLink>; Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Casanova+JL%22">Casanova JL</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.; Howard Hughes Medical Institute, New York, NY.<br /><searchLink fieldCode="AU" term="%22Puel+A%22">Puel A</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.<br /><searchLink fieldCode="AU" term="%22Bustamante+J%22">Bustamante J</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale UMR 1163, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.; Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris, Paris, France.
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