A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.
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| Title: | A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates. |
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| Authors: | Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A., Abid T; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A., Pereira Ribeiro S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A., Edara VV; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Emory Vaccine Center at Emory University, 954, Gatewood Rd, Atlanta, GA, U.S.A.; Centers for Childhood Infections and Vaccines; Children's Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, U.S.A., Floyd K; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Emory Vaccine Center at Emory University, 954, Gatewood Rd, Atlanta, GA, U.S.A.; Centers for Childhood Infections and Vaccines; Children's Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, U.S.A., Smith JC; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, U.S.A., Latif MB; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A., Pacheco-Sanchez G; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A., Dutta D; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A., Wang S; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A., Gumber S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Kirejczyk S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Cohen J; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Stammen RL; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Jean SM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Wood JS; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Pollet J; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Chen WH; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Wei J; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Zhan B; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Lee J; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Liu Z; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Strych U; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Shenvi N; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, U.S.A., Easley K; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, U.S.A., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA., Pollara J; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Mielke D; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Gao H; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Eisel N; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., LaBranche CC; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Shen X; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Ferrari G; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Tomaras GD; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Montefiori DC; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Sekaly RP; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A., Vanderford TH; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A., Tomai MA; 3M Corporate Research Materials Laboratory, St. Paul, MN, USA., Fox CB; The Infectious Disease Research Institute, Seattle, WA, USA., Suthar MS; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Emory Vaccine Center at Emory University, 954, Gatewood Rd, Atlanta, GA, U.S.A.; Centers for Childhood Infections and Vaccines; Children's Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, U.S.A., Kozlowski PA; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, U.S.A., Hotez PJ; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A. skastur@emory.edu bottazzi@bcm.edu mirko.paiardini@emory.edu.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A., Bottazzi ME; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A. skastur@emory.edu bottazzi@bcm.edu mirko.paiardini@emory.edu.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Kasturi SP; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A. skastur@emory.edu bottazzi@bcm.edu mirko.paiardini@emory.edu.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A. |
| Source: | Science immunology [Sci Immunol] 2021 Jul 15; Vol. 6 (61). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.abh3634 |
