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A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.

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Title: A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.
Authors: Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A., Abid T; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A., Pereira Ribeiro S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A., Edara VV; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Emory Vaccine Center at Emory University, 954, Gatewood Rd, Atlanta, GA, U.S.A.; Centers for Childhood Infections and Vaccines; Children's Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, U.S.A., Floyd K; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Emory Vaccine Center at Emory University, 954, Gatewood Rd, Atlanta, GA, U.S.A.; Centers for Childhood Infections and Vaccines; Children's Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, U.S.A., Smith JC; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, U.S.A., Latif MB; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A., Pacheco-Sanchez G; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A., Dutta D; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A., Wang S; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A., Gumber S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Kirejczyk S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Cohen J; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Stammen RL; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Jean SM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Wood JS; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Pollet J; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Chen WH; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Wei J; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Zhan B; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Lee J; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Liu Z; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Strych U; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Shenvi N; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, U.S.A., Easley K; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, U.S.A., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA., Pollara J; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Mielke D; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Gao H; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Eisel N; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., LaBranche CC; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Shen X; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Ferrari G; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Tomaras GD; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Montefiori DC; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Sekaly RP; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A., Vanderford TH; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A., Tomai MA; 3M Corporate Research Materials Laboratory, St. Paul, MN, USA., Fox CB; The Infectious Disease Research Institute, Seattle, WA, USA., Suthar MS; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Emory Vaccine Center at Emory University, 954, Gatewood Rd, Atlanta, GA, U.S.A.; Centers for Childhood Infections and Vaccines; Children's Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, U.S.A., Kozlowski PA; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, U.S.A., Hotez PJ; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A. skastur@emory.edu bottazzi@bcm.edu mirko.paiardini@emory.edu.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A., Bottazzi ME; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A. skastur@emory.edu bottazzi@bcm.edu mirko.paiardini@emory.edu.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A., Kasturi SP; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A. skastur@emory.edu bottazzi@bcm.edu mirko.paiardini@emory.edu.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.
Source: Science immunology [Sci Immunol] 2021 Jul 15; Vol. 6 (61).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Label: Title
  Group: Ti
  Data: A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Pino+M%22">Pino M</searchLink>; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Abid+T%22">Abid T</searchLink>; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Pereira+Ribeiro+S%22">Pereira Ribeiro S</searchLink>; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Edara+VV%22">Edara VV</searchLink>; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Emory Vaccine Center at Emory University, 954, Gatewood Rd, Atlanta, GA, U.S.A.; Centers for Childhood Infections and Vaccines; Children's Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Floyd+K%22">Floyd K</searchLink>; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Emory Vaccine Center at Emory University, 954, Gatewood Rd, Atlanta, GA, U.S.A.; Centers for Childhood Infections and Vaccines; Children's Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Smith+JC%22">Smith JC</searchLink>; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, U.S.A.<br /><searchLink fieldCode="AU" term="%22Latif+MB%22">Latif MB</searchLink>; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Pacheco-Sanchez+G%22">Pacheco-Sanchez G</searchLink>; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Dutta+D%22">Dutta D</searchLink>; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Gumber+S%22">Gumber S</searchLink>; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Kirejczyk+S%22">Kirejczyk S</searchLink>; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+J%22">Cohen J</searchLink>; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Stammen+RL%22">Stammen RL</searchLink>; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Jean+SM%22">Jean SM</searchLink>; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Wood+JS%22">Wood JS</searchLink>; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Connor-Stroud+F%22">Connor-Stroud F</searchLink>; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Pollet+J%22">Pollet J</searchLink>; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.<br /><searchLink fieldCode="AU" term="%22Chen+WH%22">Chen WH</searchLink>; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.<br /><searchLink fieldCode="AU" term="%22Wei+J%22">Wei J</searchLink>; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.<br /><searchLink fieldCode="AU" term="%22Zhan+B%22">Zhan B</searchLink>; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.<br /><searchLink fieldCode="AU" term="%22Strych+U%22">Strych U</searchLink>; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.<br /><searchLink fieldCode="AU" term="%22Shenvi+N%22">Shenvi N</searchLink>; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Easley+K%22">Easley K</searchLink>; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Weiskopf+D%22">Weiskopf D</searchLink>; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Sette+A%22">Sette A</searchLink>; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Pollara+J%22">Pollara J</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Mielke+D%22">Mielke D</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Gao+H%22">Gao H</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Eisel+N%22">Eisel N</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22LaBranche+CC%22">LaBranche CC</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Shen+X%22">Shen X</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ferrari+G%22">Ferrari G</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Tomaras+GD%22">Tomaras GD</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Montefiori+DC%22">Montefiori DC</searchLink>; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Sekaly+RP%22">Sekaly RP</searchLink>; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Vanderford+TH%22">Vanderford TH</searchLink>; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Tomai+MA%22">Tomai MA</searchLink>; 3M Corporate Research Materials Laboratory, St. Paul, MN, USA.<br /><searchLink fieldCode="AU" term="%22Fox+CB%22">Fox CB</searchLink>; The Infectious Disease Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Suthar+MS%22">Suthar MS</searchLink>; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A.; Emory Vaccine Center at Emory University, 954, Gatewood Rd, Atlanta, GA, U.S.A.; Centers for Childhood Infections and Vaccines; Children's Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Kozlowski+PA%22">Kozlowski PA</searchLink>; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, U.S.A.<br /><searchLink fieldCode="AU" term="%22Hotez+PJ%22">Hotez PJ</searchLink>; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.<br /><searchLink fieldCode="AU" term="%22Paiardini+M%22">Paiardini M</searchLink>; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A. skastur@emory.edu bottazzi@bcm.edu mirko.paiardini@emory.edu.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.<br /><searchLink fieldCode="AU" term="%22Bottazzi+ME%22">Bottazzi ME</searchLink>; Texas Children's Center for Vaccine Development, Houston, TX, U.S.A. skastur@emory.edu bottazzi@bcm.edu mirko.paiardini@emory.edu.; Department of Pediatrics, Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, U.S.A.<br /><searchLink fieldCode="AU" term="%22Kasturi+SP%22">Kasturi SP</searchLink>; Division of Microbiology and Immunology, Yerkes National Primate Research Center at Emory University, 954 Gatewood Rd, Atlanta, GA, U.S.A. skastur@emory.edu bottazzi@bcm.edu mirko.paiardini@emory.edu.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, U.S.A.
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      – TitleFull: A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.
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          Name:
            NameFull: Ferrari G
      – PersonEntity:
          Name:
            NameFull: Tomaras GD
      – PersonEntity:
          Name:
            NameFull: Montefiori DC
      – PersonEntity:
          Name:
            NameFull: Sekaly RP
      – PersonEntity:
          Name:
            NameFull: Vanderford TH
      – PersonEntity:
          Name:
            NameFull: Tomai MA
      – PersonEntity:
          Name:
            NameFull: Fox CB
      – PersonEntity:
          Name:
            NameFull: Suthar MS
      – PersonEntity:
          Name:
            NameFull: Kozlowski PA
      – PersonEntity:
          Name:
            NameFull: Hotez PJ
      – PersonEntity:
          Name:
            NameFull: Paiardini M
      – PersonEntity:
          Name:
            NameFull: Bottazzi ME
      – PersonEntity:
          Name:
            NameFull: Kasturi SP
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 07
              Text: 2021 Jul 15
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-electronic
              Value: 2470-9468
          Numbering:
            – Type: volume
              Value: 6
            – Type: issue
              Value: 61
          Titles:
            – TitleFull: Science immunology
              Type: main
ResultId 1