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A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.

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Title: A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.
Authors: Boudreau MW; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Duraki D; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Wang L; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Mao C; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Kim JE; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Henn MA; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Tang B; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Fanning SW; Ben May Department of Cancer Research, University of Chicago, Chicago, IL 60637, USA., Kiefer J; Systems Oncology, Scottsdale, AZ 85255, USA., Tarasow TM; Systems Oncology, Scottsdale, AZ 85255, USA., Bruckheimer EM; Systems Oncology, Scottsdale, AZ 85255, USA., Moreno R; Systems Oncology, Scottsdale, AZ 85255, USA., Mousses S; Systems Oncology, Scottsdale, AZ 85255, USA., Greene GL; Ben May Department of Cancer Research, University of Chicago, Chicago, IL 60637, USA., Roy EJ; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Park BH; Department of Medicine, Division of Heme/Onc, Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA., Fan TM; Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA., Nelson ER; Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA., Hergenrother PJ; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. djshapir@illinois.edu hergenro@illinois.edu.; Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Shapiro DJ; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. djshapir@illinois.edu hergenro@illinois.edu.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Source: Science translational medicine [Sci Transl Med] 2021 Jul 21; Vol. 13 (603).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Boudreau+MW%22">Boudreau MW</searchLink>; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Duraki+D%22">Duraki D</searchLink>; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Mao+C%22">Mao C</searchLink>; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Kim+JE%22">Kim JE</searchLink>; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Henn+MA%22">Henn MA</searchLink>; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Tang+B%22">Tang B</searchLink>; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Fanning+SW%22">Fanning SW</searchLink>; Ben May Department of Cancer Research, University of Chicago, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Kiefer+J%22">Kiefer J</searchLink>; Systems Oncology, Scottsdale, AZ 85255, USA.<br /><searchLink fieldCode="AU" term="%22Tarasow+TM%22">Tarasow TM</searchLink>; Systems Oncology, Scottsdale, AZ 85255, USA.<br /><searchLink fieldCode="AU" term="%22Bruckheimer+EM%22">Bruckheimer EM</searchLink>; Systems Oncology, Scottsdale, AZ 85255, USA.<br /><searchLink fieldCode="AU" term="%22Moreno+R%22">Moreno R</searchLink>; Systems Oncology, Scottsdale, AZ 85255, USA.<br /><searchLink fieldCode="AU" term="%22Mousses+S%22">Mousses S</searchLink>; Systems Oncology, Scottsdale, AZ 85255, USA.<br /><searchLink fieldCode="AU" term="%22Greene+GL%22">Greene GL</searchLink>; Ben May Department of Cancer Research, University of Chicago, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Roy+EJ%22">Roy EJ</searchLink>; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Park+BH%22">Park BH</searchLink>; Department of Medicine, Division of Heme/Onc, Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Fan+TM%22">Fan TM</searchLink>; Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+ER%22">Nelson ER</searchLink>; Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Hergenrother+PJ%22">Hergenrother PJ</searchLink>; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. djshapir@illinois.edu hergenro@illinois.edu.; Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Shapiro+DJ%22">Shapiro DJ</searchLink>; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. djshapir@illinois.edu hergenro@illinois.edu.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
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